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FLASH GENE
Symbol KCNH6 contributors: mct/npt - updated : 05-03-2014
HGNC name potassium voltage-gated channel, subfamily H (eag-related), member 6
HGNC id 18862
DNA
TYPE functioning gene
STRUCTURE 25.64 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 splicing 3421 109.9 994 - 2004 15202000
15 splicing 3017 - 905 - 2004 15202000
lackng two internal segments
13 - 3783 - 958 - 2004 15202000
13 - 3650 - 835 - 2004 15202000
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
nervousbraindiencephalon   
Nervousbrainhindbraincerebellum  
Reproductivemale systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines prolactine adenoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal cytoplasmic domain with PAS (PER-ARNT-SIM) dimerization domain and PAC (PAS-associated C-terminal) domain
  • six transmembrane domains the fourth being the voltage-sensor site
  • a pore forming domain (H5) between the fifth and sixth transmembrane domains
  • C-terminal region containing a cyclic-nucleotide-binding homology domain (CNBHD) and C-linker that couples the CNBHD to the pore
  • mono polymer homomer , heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • potassium channel family
  • H (EAG) subfamily
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • pore forming (alpha) subunit of voltage-gated potassium channel
  • forms the ion channel responsible for the rapidly acting delayed rectifier potassium current, I(Kr), and its blockade is a significant contributor to prolongation of the QT interval (Yoshida 2006)
  • selectively involved in proliferation of distinct uterine cancer cells (Suzuki 2004)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    text prolactine secretion
    PATHWAY
    metabolism
    signaling
    a component
  • KCNH2, KCNH7
  • part of ERG channels control the excitability of medial vestibular nucleus neurones, their discharge regularity and probably their resonance properties (Pessia 2008)
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • cyclic nucleotide (cAMP)
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS