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FLASH GENE
Symbol KATNB1 contributors: mct/npt - updated : 26-11-2014
HGNC name katanin p80 (WD repeat containing) subunit B 1
HGNC id 6217
Location 16q13      Physical location : 57.769.659 - 57.791.162
Synonym name
  • katanin (80 kDa)
  • katanin p80 WD40-containing subunit B1
  • Synonym symbol(s) KAT
    DNA
    TYPE functioning gene
    STRUCTURE 21.53 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site
    text structure
  • a 518- bp TATA-less promoter including a critical CpG island and GC boxes as an optimal promoter, and sequential deletion of CpG island and the GC elements gradually decreased the KATNB1 promoter activity
  • MAPPING cloned Y linked N status provisional
    Physical map
    SLC12A3 16q13 solute carrier family 12 (sodium/chloride transporters), member 3 HERPUD1 16q12.2-13 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 CETP 16q13 cholesteryl ester transfer protein, plasma NOD27 16q13 nucleotide-binding oligomerization domains 27 CPNE2 16q13 copine II NIP30 16q13 NEFA-interacting nuclear protein NIP30 KIAA1972 16q13 KIAA1972 protein TM4SF11 16q12-q13 transmembrane 4 superfamily member 11 (plasmolipin) BART1 CX3CL1 16q13 chemokine (C-X3-C motif) ligand 1 CCL22 16q13 chemokine (C-C motif) ligand 22 CCL17 16q13 chemokine (C-C motif) ligand 17 LOC57019 16q13-q21 hypothetical protein LOC57019 POLR2C 16q13-q21 polymerase (RNA) II (DNA directed) polypeptide C, 33kDa DOK4 16q13 docking protein 4 MGC10992 16q13 hypothetical protein LOC92922 GPR114 16q13 G protein-coupled receptor 114 LOC255519 16q13 similar to high mobility group protein homolog HMG4 GPR56 16q13 G protein-coupled receptor 56 GPR97 16q13 G protein-coupled receptor 97 DKFZp434I099 16q13 hypothetical protein DKFZp434I099 KATNB1 16q13 katanin p80 (WD repeat containing) subunit B 1 KIFC3 16q13-q21 kinesin family member C3 LOC388282 16 hypothetical gene supported by AF452719; BC041062 CNGB1 16q13 cyclic nucleotide gated channel beta 1 TEPP 16q13 testis/prostate/placenta-expressed protein ZNF319 16q21 zinc finger protein 319 FLJ13154 16q13 hypothetical protein FLJ13154 MMP15 16q13-q21 matrix metalloproteinase 15 (membrane-inserted) GTL3 16q13 likely ortholog of mouse gene trap locus 3 CSNK2A2 16p13.3-p13.2 casein kinase 2, alpha prime polypeptide HSPC065 16q13 HSPC065 protein FLJ13912 16q13 hypothetical protein FLJ13912 NDRG4 16q21-q22.3 NDRG family member 4 FLJ21148 16q13 hypothetical protein FLJ21148 KIAA1007 16q21 hypothetical protein FLJ21148
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 2661 80 655 - 2012 22654669
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal WD40 repeat domain
  • a C terminal microtubule binding domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • WD repeat KATNB1 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • present during spermatid development, and in particular localized to the microtubules of the manchette, a structure required for sperm head shaping
  • basic FUNCTION
  • targeting the p60 subunit KATNA1 to the centrosome
  • is essential for male fertility
  • KATNB1, most likely in association with KATNA1, has an essential role in male meiotic spindle assembly and dissolution and the removal of midbody microtubules and, thus, cytokinesis
  • serves an essential and evolutionarily conserved role in several aspects of male germ cell development
  • consists of multiple domains with different functions such as targeting KATNA1 to the centrosome, augmenting microtubule severing by KATNA1, and even suppressing microtubule severing
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text assembly and function of the mitotic spindle
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with KATNA1 (p60)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • spindle-pole proteins
  • interacting with LZTS2 (participates in cytokinesis by interacting with KATNB1, the disruption of which may potentially cause genetic instability and cancer) (Sudo 2007)
  • interaction with NDEL1 (essential for mitotic cell division and neuronal migration not only via regulation of cytoplasmic dynein function but also by modulation of KATNB1 localization and function) (Toyo-Oka 2005)
  • ELK1 activated KATNB1 promoter
  • cell & other
    REGULATION
    Other regulated by CUL3/KLHDC5 E3 ligase (regulatory mechanism that occurs at the level of targeted proteolysis to allow normal mitotic progression in cells) (Cummings 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism other
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS