SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus
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| present during spermatid development, and in particular localized to the microtubules of the manchette, a structure required for sperm head shaping |
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shuttles between the nucleus and spindle pole in synchrony with the cell cycle |
basic FUNCTION
| targeting the p60 subunit KATNA1 to the centrosome |
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is essential for male fertility |
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KATNB1, most likely in association with KATNA1, has an essential role in male meiotic spindle assembly and dissolution and the removal of midbody microtubules and, thus, cytokinesis |
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serves an essential and evolutionarily conserved role in several aspects of male germ cell development |
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consists of multiple domains with different functions such as targeting KATNA1 to the centrosome, augmenting microtubule severing by KATNA1, and even suppressing microtubule severing |
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functions for KATNB1 in regulating overall centriole, mother centriole, and cilia number, and as an essential gene for normal Hedgehog signaling during neocortical development |
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role in spindle formation |
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KATNB1 regulates microtubule (MT) remodeling in combination with NUMA1 (nuclear mitotic apparatus protein) and cytoplasmic dynein |
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KATNB1 function is a critical regulator of heart development |