Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | JAK1 | contributors: mct/npt/pgu - updated : 03-06-2020 |
HGNC name | Janus kinase 1 |
HGNC id | 6190 |
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Location | 1p31.3 Physical location : 65.298.905 - 65.432.187 |
Synonym name | Janus kinase 1 (a protein tyrosine kinase) |
Synonym symbol(s) | JAK1A, JAK1B, JTK3, JAK-1, JAK1AB |
EC.number | 2.7.1.112, 2.7.10.1 |
DNA |
TYPE | functioning gene |
STRUCTURE | 234.52 kb 25 Exon(s) |
Genomic sequence alignment details |
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10 Kb 5' upstream gene genomic sequence study |
MAPPING | cloned | Y | linked | Y | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
interspecies | homolog to murine Fd-22 |
intraspecies | paralog to JAK2 |
paralog to JAK3 |
Homologene |
FAMILY | |
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CATEGORY | enzyme |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,organelle,membrane | |
intracellular,cytoplasm,organelle,endosome | |
intracellular,cytoplasm,cytosolic | |
intracellular,cytoplasm,cytoskeleton | |
intracellular,nucleus | |
text | possibly membrane anchored |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling | signal transduction |
interferon alpha-beta-gamma signal transduction |
a component |
INTERACTION |
DNA |
RNA |
small molecule | nucleotide, |
protein | |
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cell & other |
REGULATION |
activated by | cytokine receptors gamma chain |
Other | regulated by phosphorylation of tyrosine residues in the putative activation loops of the kinase domain |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |