protein
| mediating activation of STAT proteins (STAT5) |
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associating with gamma chain of cytokine receptors |
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binding and inhibited by SOCS1  |
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cooperation between PTPN2 deletion and activating JAK1 gene mutations in T-cell acute lymphoblastic leukemia  |
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TJP2 associates with JAK1 in vascular smooth muscle cells via TJP2 N-terminal fragment, and JAK1 serves for tyrosine phosphorylation of TJP2 in VSMC  |
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NK cell activation and secretion of IFNG1 results in activation of JAK1, JAK2 and STAT1 in tumor cells, resulting in rapid up-regulation of CD274 expression  |
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CISH interacted with the tyrosine kinase JAK1, inhibiting its enzymatic activity and targeting JAK for proteasomal degradation (  |
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SOCS1 negatively regulates IFNG1 signaling pathway (and other pathways) by directly inhibiting JAK1, JAK2  |
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CLDN10 enhanced the metastatic phenotype of osteosarcoma (OS) cells via the activation of the JAK1/STAT1 signaling pathway  |