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FLASH GENE
Symbol JAG2 contributors: mct/pgu - updated : 30-11-2011
HGNC name jagged 2
HGNC id 6189
Location 14q32.33      Physical location : 105.608.076 - 105.635.161
Synonym symbol(s) HJ2, SER2
DNA
TYPE functioning gene
STRUCTURE 27.09 kb     25 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC388021 14 similar to expressed sequence AI839735 MGC13251 14q32.33 hypothetical protein MGC13251 FLJ22056 14q32.33 hypothetical protein FLJ22056 LOC388022 14 hypothetical gene supported by AK131040 ADSSL1 14q32.33 adenylosuccinate synthase like 1 SIVA 14q32.33 CD27-binding (Siva) protein AKT1 14q32.32 v-akt murine thymoma viral oncogene homolog 1 LOC390508 14 similar to MGC53446 protein MGC23270 14q32.33 hypothetical protein MGC23270 RPS2P4 14q32.33 ribosomal protein S2 pseudogene 4 KIAA0284 14q32.33 KIAA0284 LOC122618 14q32.33 hypothetical protein BC015003 C14orf78 14 chromosome 14 open reading frame 78 C14orf157 14q32.33 chromosome 14 open reading frame 157 C14orf79 14q32.33 chromosome 14 open reading frame 79 CDCA4 14q32.33 cell division cycle associated 4 GPR132 14q32.3 G protein-coupled receptor 132 JAG2 14q32 jagged 2 NUDT14 14q32.33 nudix (nucleoside diphosphate linked moiety X)-type motif 14 LOC390509 14 similar to chloride intracellular channel 6; chloride channel form A BRF1 14q32.33 BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) BTBD6 14q32 BTB (POZ) domain containing 6 MTA1 14q32.3 metastasis associated 1 CRIP1 7q11.23 cysteine-rich protein 1 (intestinal) CRIP2 14q32.3 cysteine-rich protein 2 LOC388024 14 LOC388024 C14orf80 14q32.33 chromosome 14 open reading frame 80 MGC4659 14q32.33 hole gene ATP5GP3 14q32.33 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9) pseudogene 3 LOC390510 14 similar to ELK1, member of ETS oncogene family LOC388025 14 similar to Ig alpha-2 chain C region LOC388026 14 similar to Ig epsilon chain C region
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 - 5077 - 1238 - 2011 21372153
  • isoform a
  • 25 - 4963 129.3 1200 - 2011 21372153
  • isoform b
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Hearing/Equilibriumear    
    Nervousnerve   highly
    Reproductivefemale systembreastmammary gland highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text highly in embryonic limb buds, first branchial arch, developing cochlea and the organ of Corti, central and peripheral nervous system, retina, tooth buds, thymus, submandilas gland, stomach
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • a DSL (Delta, Serrate, Lag2) domain
  • 16 EGF-like repeats
  • a cysteine-rich extracellular region
  • isoforms Precursor
    HOMOLOGY
    interspecies homolog to rattus Jag2
    homolog to Drosophila serrate Dress30
    homolog to murine
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • overexpression may be an early event in the pathogenesis of multiple myeloma involving IL6 production
  • play dual roles as activators of Notch receptor signaling and as receptors that mediate nuclear signaling events via gamma-secretase-generated cytoplasmic domain
  • critical role for JAG2-Notch signaling in the maintenance of proliferating neural precursors in a discrete compartment of the neural tube during the continuing growth and development of the vertebrate nervous system
  • JAG2-Notch axis plays a crucial role in dendritic cells-mediated NK cell cytotoxicity
  • can regulate the expression of cytokines that can promote antitumor immunity
  • its expression by dendritic cells is not sufficient or required for Th2 cell differentiation
  • IRF6 and the Notch ligand JAG2 function in convergent molecular pathways during oral epithelial differentiation
  • like Delta-like ligands, induces T-lineage differentiation and inhibits B-cell and myeloid development
  • unexpected functional similarity between JAG2 and the Delta-like ligands
  • hypoxic induction of JAG2 in tumor cells mediates a hypoxia-regulated cross-talk between tumor and endothelial cells
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text inner ear
    PATHWAY
    metabolism
    signaling sensory transduction/hearing
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for NOTCH1 (acts synergistically with DLL1, to regulate hair cell development in the mammalian inner ear)
  • interacting with IRF6 (IRF6 and JAG2 function in convergent molecular pathways during development of the oral ectoderm)
  • weaker NOTCH1-activator compared with the Delta-like ligands, revealing a NOTCH1 specific signal strength hierarchy for mammalian NOTCH ligands
  • cell & other
    REGULATION
    activated by transcriptionally activated by hypoxia in a HIF-1a dependent manner
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in malignant plasma cells from multiple myeloma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS