| 1 | JAG2, LGMDR27
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| A form of muscular dystrophy associated with pathogenic variants in JAG2. 2021 PMID:
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| Coppens S, Barnard AM, Puusepp S, Pajusalu S, Õunap K, Vargas-Franco D, Bruels CC, Donkervoort S, Pais L, Chao KR, Goodrich JK, England EM, Weisburd B, Ganesh VS, Gudmundsson S, O'Donnell-Luria A, Nigul M, Ilves P, Mohassel P, Siddique T, Milone M, Nicolau S, Maroofian R, Houlden H, Hanna MG, Quinlivan R, Beiraghi Toosi M, Ghayoor Karimiani E, Costagliola S, Deconinck N, Kadhim H, Macke E, Lanpher BC, Klee EW, Łusakowska A, Kostera-Pruszczyk A, Hahn A, Schrank B, Nishino I, Ogasawara M, El Sherif R, Stojkovic T, Nelson I, Bonne G, Cohen E, Boland-Augé A, Deleuze JF, Meng Y, Töpf A, Vilain C, Pacak CA, Rivera-Zengotita ML, Bönnemann CG, Straub V, Handford PA, Draper I, Walter GA, Kang PB
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| Am J Hum Genet. May 6;108(5):840-856. doi: 10.1016/j.ajhg.2021.03.020. Epub 2021 Apr 15. 2021
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| 2 | JAG2
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| Mutual regulation of JAG2 and PRAF2 promotes migration and invasion of colorectal cancer cells uncoupled from epithelial-mesenchymal transition
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| He W, Tang J, Li W, Li Y, Mei Y, He L, Zhong K, Xu R.
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| Cancer Cell Int. Jun 11;19:160. doi: 10.1186/s12935-019-0871-5. 2019
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| 3 | JAG2, YAP1
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| Muscle contraction is required to maintain the pool of muscle progenitors via YAP and NOTCH during fetal myogenesis
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| Esteves de Lima J, Bonnin MA, Birchmeier C, Duprez D.
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| Elife. Aug 24;5:e15593. doi: 10.7554/eLife.15593. 2016
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| 4 | JAG2
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| Jagged 2 silencing inhibits motility and invasiveness of colorectal cancer cell lines.
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| He W, Chan CM, Wong SC, Au TC, Ho WS, Chan AK, Chan AS, Ma BB, Chan AT.
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| Oncol Lett. Dec;12(6):5193-5198. doi: 10.3892/ol.2016.5321. Epub 2016 Oct 26 2016
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| 5 | JAG2
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| Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells
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| Xishan Z, Bin Z, Haiyue Z, Xiaowei D, Jingwen B, Guojun Z.
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| Sci Rep. Sep 28;5:14284. doi: 10.1038/srep14284. 2015
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| 6 | BACE1, JAG1, JAG2
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| β-site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) proteins.
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| He W, Hu J, Xia Y, Yan R.
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| J Biol Chem. Jul 25;289(30):20630-7. doi: 10.1074/jbc.M114.579862. 2014
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| 7 | JAG1, JAG2
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| NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma
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| Fiaschetti G, Schroeder C, Castelletti D, Arcaro A, Westermann F, Baumgartner M, Shalaby T, Grotzer MA.
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| Acta Neuropathol Commun. Apr 7;2:39. doi: 10.1186/2051-5960-2-39. 2014
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| 8 | JAG2
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| Jagged2 controls the generation of motor neuron and oligodendrocyte progenitors in the ventral spinal cord.
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| Rabadán MA, Cayuso J, Le Dréau G, Cruz C, Barzi M, Pons S, Briscoe J, Martí E.
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| Cell Death Differ. Feb;19(2):209-19. doi: 10.1038/cdd.2011.84. Epub 2011 Jul 1. 2012
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| 9 | JAG1, JAG2
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| Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.
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| Van de Walle I, De Smet G, Gärtner M, De Smedt M, Waegemans E, Vandekerckhove B, Leclercq G, Plum J, Aster JC, Bernstein ID, Guidos CJ, Kyewski B, Taghon T.
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| Blood 117(17):4449-59. Epub 2011 Mar 3.
2011
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| 10 | JAG2
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| JAG2 induction in hypoxic tumor cells alters Notch signaling and enhances endothelial cell tube formation.
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| Pietras A, von Stedingk K, Lindgren D, Påhlman S, Axelson H.
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| Mol Cancer Res 9(5):626-36. Epub 2011 Mar 14.
2011
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| 11 | JAG2
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| Differential regulation of Notch ligands in dendritic cells upon interaction with T helper cells.
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| Sauma D, Espejo P, Ramirez A, Fierro A, Rosemblatt M, Bono MR.
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| Scand J Immunol 74(1):62-70. doi: 10.1111/j.1365-3083.2011.02541.x.
2011
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| 12 | JAG1, JAG2
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| Distinct biological roles for the notch ligands Jagged-1 and Jagged-2.
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| Choi K, Ahn YH, Gibbons DL, Tran HT, Creighton CJ, Girard L, Minna JD, Qin FX, Kurie JM.
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| J Biol Chem 284(26):17766-74. Epub 2009 Apr 27.
2009
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| 13 | IRF6, JAG2
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| Integration of IRF6 and Jagged2 signalling is essential for controlling palatal adhesion and fusion competence.
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| Richardson RJ, Dixon J, Jiang R, Dixon MJ.
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| Hum Mol Genet 18(14):2632-42. Epub 2009 May 13. 2009
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| 14 | JAG2
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| Loss of the SMRT/NCoR2 corepressor correlates with JAG2 overexpression in multiple myeloma.
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| Ghoshal P, Nganga AJ, Moran-Giuati J, Szafranek A, Johnson TR, Bigelow AJ, Houde CM, Avet-Loiseau H, Smiraglia DJ, Ersing N, Chanan-Khan AA, Coignet LJ.
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| Cancer Res 69(10):4380-7. Epub 2009 May 5.
2009
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| 15 | ANGPT2, EPHB3, JAG2, NETO2, NOTCH4
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| Identification of signaling systems in proliferating and involuting phase infantile hemangiomas by genome-wide transcriptional profiling.
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| Calicchio ML, Collins T, Kozakewich HP.
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| Am J Pathol 174(5):1638-49. Epub 2009 Apr 6.PMID: 19349369 2009
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| 16 | JAG2
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| Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction.
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| Kijima M, Yamaguchi T, Ishifune C, Maekawa Y, Koyanagi A, Yagita H, Chiba S, Kishihara K, Shimada M, Yasutomo K.
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| Proc Natl Acad Sci U S A 105(19):7010-5. Epub 2008 May 5.
2008
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| 17 | JAG2
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| Jagged-mediated Notch signaling maintains proliferating neural progenitors and regulates cell diversity in the ventral spinal cord.
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| Yeo SY, Chitnis AB.
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| Proc Natl Acad Sci U S A 104(14):5913-8. Epub 2007 Mar 26.
2007
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| 18 | DLL1,JAG2
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| The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.
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| Kiernan AE, Cordes R, Kopan R, Gossler A, Gridley T.
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| Development 132(19):4353-62. Epub 2005 Sep 1. 2005
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| 19 | JAG2
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| Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines.
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| Houde C, Li Y, Song L, Barton K, Zhang Q, Godwin J, Nand S, Toor A, Alkan S, Smadja NV, Avet-Loiseau H, Lima CS, Miele L, Coignet LJ.
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| Blood 104(12):3697-704. Epub 2004 Aug 3. 2004
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| 20 | CADASIL, DLL1, Dll3, DLL4, JAG1, JAG2, NOTCH1, NOTCH2, NOTCH3, NOTCH4 , RBPJ, SCDO1
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| Notch signaling and inherited disease syndromes.
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| Gridley T.
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| Hum Mol Genet 12 Spec No 1:R9-13. Review. 2003
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| 21 | DLL1,JAG2
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| The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent gamma-secretase cleavage.
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| Ikeuchi T, Sisodia SS.
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| J Biol Chem 278(10):7751-4. Epub 2003 Jan 24. 2003
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| 22 | JAG2, NOTCH1
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| Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes.
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| Hayashi T, Kageyama Y, Ishizaka K, Xia G, Kihara K, Oshima H.
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| J Androl 22(6):999-1011. 2001
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| 23 | JAG2, NUDT14
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| Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene.
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| Deng Y, Madan A, Banta AB, Friedman C, Trask BJ, Hood L, Li L.
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| Genomics 63(1):133-8. 2000
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| 24 | JAG2, NOTCH1
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| Notch signalling pathway mediates hair cell development in mammalian cochlea.
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| Lanford PJ, et al.
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| Nat Genet 21(3):289-92. 1999
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| 25 | JAG2
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| Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice.
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| Jiang R, et al.
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| Genes Dev 12 : 1046-1057. 1998
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| 26 | DYRK1A, EHD1, EMX1, EYA3, JAG2, UBE3A, USP9Y
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| The embryonic expression pattern of 40 murine cDNAs homologous to Drosophila mutant genes (Dres) : a comparative and topographic approach to predict gene function.
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| Bulfone A, et al.
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| Hum Mol Genet 7 : 1997-2006. 1998
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| 27 | JAG2
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| Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor.
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| Luo B, et al.
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| Mol Cell Biol 17 : 6057-6067. 1997
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| 28 | JAG2
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| Serrate2 is disrupted in the mouse limb-development mutant syndactylism.
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| Sidow A, et al.
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| Nature 389 : 722-725. 1997
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