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FLASH GENE

Symbol

IYD

contributors: mct/np - updated : 28-02-2009

HGNC name	iodotyrosine deiodinase
HGNC id	21071

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q25.1      Physical location : 150.690.027 - 150.725.764
Synonym name	iodotyrosine dehalogenase 1
	chromosome 6 open reading frame 71
Synonym symbol(s)	DEHAL1, dJ422F24.1, C6orf71
EC.number	1.-.-.-

DNA

TYPE	functioning gene
STRUCTURE	35.74 kb     5 Exon(s)

regulatory sequence

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_203395 5 splicing 7419 NP_981932 33 289 - Gnidehou (2004), Afink (2008) also called variant 2 NM_001164694 - splicing 7531 NP_001158166 33 293 - Gnidehou (2004) also called EHAL1B or variant 1 NM_001164695 - splicing 7480 NP_001158167 32 247 - Gnidehou (2004) also called variant 3

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   moderately Endocrine thyroid       highly Reproductive female system breast mammary gland   moderately Urinary kidney       specific

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal domain providing a membrane anchor
	intermediate domain with the highest sequence variability and lacking homology to structural motifs available in the common databases
	C-terminal domain highly conserved that resembles bacterial enzymes of the NADH oxidase/flavin reductase superfamily (Friedman 2006)

HOMOLOGY

Homologene

FAMILY

nitroreductase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
text	accumulate at the apical pole of thyrocytes

basic FUNCTION	catalyzing the NADPH-dependent deiodination of mono (L-MIT) and diiodotyrosine (L-DIT), with greater activity vs. L-MIT
	involved in the recycling of iodide close to the thyroglobulin iodination site
	in the thyroid controls the reuse of iodide for thyroid hormone synthesis (Moreno 2008)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

other

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS