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FLASH GENE
Symbol IYD contributors: mct/np - updated : 28-02-2009
HGNC name iodotyrosine deiodinase
HGNC id 21071
DNA
TYPE functioning gene
STRUCTURE 35.74 kb     5 Exon(s)
regulatory sequence
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 splicing 7419 33 289 - Gnidehou (2004), Afink (2008)
also called variant 2
- splicing 7531 33 293 - Gnidehou (2004)
also called EHAL1B or variant 1
- splicing 7480 32 247 - Gnidehou (2004)
also called variant 3
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
Endocrinethyroid   highly
Reproductivefemale systembreastmammary gland moderately
Urinarykidney   specific
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain providing a membrane anchor
  • intermediate domain with the highest sequence variability and lacking homology to structural motifs available in the common databases
  • C-terminal domain highly conserved that resembles bacterial enzymes of the NADH oxidase/flavin reductase superfamily (Friedman 2006)
  • HOMOLOGY
    Homologene
    FAMILY
  • nitroreductase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text accumulate at the apical pole of thyrocytes
    basic FUNCTION
  • catalyzing the NADPH-dependent deiodination of mono (L-MIT) and diiodotyrosine (L-DIT), with greater activity vs. L-MIT
  • involved in the recycling of iodide close to the thyroglobulin iodination site
  • in the thyroid controls the reuse of iodide for thyroid hormone synthesis (Moreno 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS