| basic FUNCTION
| tyrosine kinase |
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involved in regulating antigen receptor induced serum response factor (SRF) activation |
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critical role for ITK and TXK in conventional CD8(+) T cell development in the thymus  |
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ITK and TXK are required for efficient positive selection of conventional CD4+ and CD8+ T cells in the thymus |
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important role for ITK and TXK in the development of conventional as opposed to innate CD4(+) and CD8(+) T cells |
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play critical roles in helping shape immune responses via their effects on the differentiation and function of distinct cytokine-producing, effector T-cell populations |
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serves as a modulator, or rheostat, critically fine-tuning the T cell response |
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required for efficient replication of influenza virus in infected T-cells |
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Tec-family kinase that regulates the spatiotemporal organization of components of T cell signaling pathways and CDC42-dependent actin polymerization |
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ITK signaling promotes IRF4 up-regulation following CD8(+) T-cell activation and that this signaling pathway normally suppresses EOMES expression, thereby regulating the differentiation pathway of CD8(+) T cells |
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critical for the recruitment of the kinase to the plasma membrane and its co-localization with the TCR-CD3 molecular complex |
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catalyzes phosphorylation on tyrosine residues within a number of its natural substrates, including the well-characterized gamma783 of PLCG1 |
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involved in T-cell proliferation and differentiation |
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important for the activation of T cells via the T cell Receptor (TCR) |
