| 1 | GNA13, ITK
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| The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with Gα13 and activation of serum response factor.
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| Huang W, Morales JL, Gazivoda VP, Lai J, Qi Q, August A.
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| Int J Biochem Cell Biol nt J Biochem Cell Biol. 2013 Feb 27. doi:pii: S1357-2725(13)00057-5. 10.1016/j.biocel.2013.02.011. [Epub ahead of print]
2013
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| 2 | ITK
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| The Tec Kinase ITK Regulates Thymic Expansion, Emigration, and Maturation of γδ NKT Cells.
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| Yin CC, Cho OH, Sylvia KE, Narayan K, Prince AL, Evans JW, Kang J, Berg LJ.
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| J Immunol 190(6):2659-69. doi: 10.4049/jimmunol.1202531. Epub 2013 Feb 1.
2013
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| 3 | ITK, PLCG1
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| Substrate recognition of PLCγ1 via a specific docking surface on Itk.
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| Xie Q, Joseph RE, Fulton DB, Andreotti AH.
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| J Mol Biol 425(4):683-96. doi: 10.1016/j.jmb.2012.10.023. Epub 2012 Dec 3.
2013
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| 4 | ITK, LCP2, SYK
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| Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK (spleen tyrosine kinase) fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70.
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| Hussain A, Mohammad DK, Gustafsson MO, Uslu M, Hamasy A, Nore BF, Mohamed AJ, Smith CI.
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| J Biol Chem 288(10):7338-50. doi: 10.1074/jbc.M112.374967. Epub 2013 Jan 4.
2013
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| 5 | EOMES, IRF4, ITK
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| TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation.
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| Nayar R, Enos M, Prince A, Shin H, Hemmers S, Jiang JK, Klein U, Thomas CJ, Berg LJ.
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| Proc Natl Acad Sci U S A 109(41):E2794-802. doi: 10.1073/pnas.1205742109. Epub 2012 Sep 24.
2012
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| 6 | ITK
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| A conserved motif in the ITK PH-domain is required for phosphoinositide binding and TCR signaling but dispensable for adaptor protein interactions.
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| Hirve N, Levytskyy RM, Rigaud S, Guimond DM, Zal T, Sauer K, Tsoukas CD.
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| PLoS One 7(9):e45158. doi: 10.1371/journal.pone.0045158. Epub 2012 Sep 18.
2012
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| 7 | DEF6, ITK
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| DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies.
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| Hey F, Czyzewicz N, Jones P, Sablitzky F.
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| J Biol Chem 287(37):31073-84. doi: 10.1074/jbc.M112.346767. Epub 2012 Jul 24.
2012
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| 8 | ITK, PLCG1
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| Inhibitors of interleukin-2 inducible T-cell kinase as potential therapeutic candidates for the treatment of various inflammatory disease conditions.
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| Kaur M, Bahia MS, Silakari O.
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| Eur J Pharm Sci 47(3):574-88. doi: 10.1016/j.ejps.2012.07.013. Epub 2012 Jul 20. Review.
2012
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| 9 | ITK
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| Regulation of T-cell responses and disease by tec kinase Itk.
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| August A, Ragin MJ.
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| Int Rev Immunol 31(2):155-65. doi: 10.3109/08830185.2012.668981. Review.
2012
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| 10 | ITK
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| Role of Itk signalling in the interaction between influenza A virus and T-cells.
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| Fan K, Jia Y, Wang S, Li H, Wu D, Wang G, Chen JL.
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| J Gen Virol 93(Pt 5):987-97. doi: 10.1099/vir.0.041228-0. Epub 2012 Feb 1.
2012
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| 11 | ITK, TXK
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| A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice.
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| Qi Q, Huang W, Bai Y, Balmus G, Weiss RS, August A.
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| J Immunol 188(8):3611-9. doi: 10.4049/jimmunol.1102475. Epub 2012 Mar 7.
2012
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| 12 | DEF6, ITK
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| Itk controls the spatiotemporal organization of T cell activation.
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| Singleton KL, Gosh M, Dandekar RD, Au-Yeung BB, Ksionda O, Tybulewicz VL, Altman A, Fowell DJ, Wülfing C.
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| Sci Signal 4(193):ra66. doi: 10.1126/scisignal.2001821.
2011
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| 13 | ITK
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| Itk: the rheostat of the T cell response.
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| Grasis JA, Tsoukas CD.
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| J Signal Transduct 2011:297868. doi: 10.1155/2011/297868. Epub 2011 Apr 7.
2011
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| 14 | ITK, TXK
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| Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates.
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| Gomez-Rodriguez J, Kraus ZJ, Schwartzberg PL.
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| FEBS J 278(12):1980-9. doi: 10.1111/j.1742-4658.2011.08072.x. Epub 2011 Mar 29. Review.
2011
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| 15 | ITK, LCP2
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| In vivo significance of ITK-SLP-76 interaction in cytokine production.
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| Grasis JA, Guimond DM, Cam NR, Herman K, Magotti P, Lambris JD, Tsoukas CD.
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| Mol Cell Biol 30(14):3596-609. doi: 10.1128/MCB.01657-09. Epub 2010 May 10.
2010
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| 16 | ITK, LCK, SH2D2A
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| T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells.
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| Berge T, Sundvold-Gjerstad V, Granum S, Andersen TC, Holthe GB, Claesson-Welsh L, Andreotti AH, Inngjerdingen M, Spurkland A.
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| PLoS One 5(3):e9761. doi: 10.1371/journal.pone.0009761.
2010
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| 17 | ITK
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| Disrupting the intermolecular self-association of Itk enhances T cell signaling.
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| Min L, Wu W, Joseph RE, Fulton DB, Berg L, Andreotti AH.
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| J Immunol 184(8):4228-35. doi: 10.4049/jimmunol.0901908. Epub 2010 Mar 17.
2010
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| 18 | ITK, PLCG1
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| Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1.
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| Min L, Joseph RE, Fulton DB, Andreotti AH.
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| Proc Natl Acad Sci U S A 106(50):21143-8. doi: 10.1073/pnas.0911309106. Epub 2009 Dec 1.
2009
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| 19 | ITK
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| The Tec family kinase Itk exists as a folded monomer in vivo.
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| Qi Q, August A.
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| J Biol Chem 284(43):29882-92. doi: 10.1074/jbc.M109.003129. Epub 2009 Aug 28.
2009
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| 20 | ITK
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| SH2-dependent autophosphorylation within the Tec family kinase Itk.
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| Joseph RE, Severin A, Min L, Fulton DB, Andreotti AH.
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| J Mol Biol 391(1):164-77. doi: 10.1016/j.jmb.2009.06.023. Epub 2009 Jun 11.
2009
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| 21 | ITK, RXK
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| The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development.
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| Prince AL, Yin CC, Enos ME, Felices M, Berg LJ.
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| Immunol Rev 228(1):115-31. doi: 10.1111/j.1600-065X.2008.00746.x. Review.
2009
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| 22 | ITK
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| The Tec family kinase, IL-2-inducible T cell kinase, differentially controls mast cell responses.
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| Iyer AS, August A.
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| J Immunol 180(12):7869-77.
2008
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| 23 | ITK, TXK
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| Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.
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| Sahu N, Venegas AM, Jankovic D, Mitzner W, Gomez-Rodriguez J, Cannons JL, Sommers C, Love P, Sher A, Schwartzberg PL, August A.
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| J Immunol 181(9):6125-31.
2008
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| 24 | ITK, TXK
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| The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival.
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| Felices M, Berg LJ.
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| J Immunol 180(5):3007-18.
2008
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| 25 | ITK, LCP2
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| SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK.
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| Bogin Y, Ainey C, Beach D, Yablonski D.
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| Proc Natl Acad Sci U S A 104(16):6638-43. Epub 2007 Apr 9.
2007
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| 26 | ITK
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| A kinase independent function for Tec kinase ITK in regulating antigen receptor induced serum response factor activation.
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| Hao S, Qi Q, Hu J, August A.
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| FEBS Lett 580(11):2691-7. Epub 2006 Apr 19. 2006
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| 27 | ITK
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| Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptors.
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| Qi Q, Sahu N, August A.
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| J Biol Chem 281(50):38529-34. Epub 2006 Oct 23. 2006
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| 28 | ITK, RXK
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| The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells.
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| Atherly LO, Lucas JA, Felices M, Yin CC, Reiner SL, Berg LJ.
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| Immunity 25(1):79-91.
2006
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| 29 | ITK, PPIA
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| Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A.
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| Brazin KN, Mallis RJ, Fulton DB, Andreotti AH.
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| Proc Natl Acad Sci U S A 99(4):1899-904. 2002
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| 30 | ITK
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| Localization of the human IL-2-inducible T-cell kinase gene (ITK) to chromosome band 5q34 and the mouse gene (Itk) to chromosome 15 by fluorescence in situ hybridization.
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| Tate G, et al.
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| Cytogenet Cell Genet 74 : 96-98. 1996
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| 31 | ITK
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| Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q.
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| Janis EM, et al.
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| Genomics 23 : 269-271. 1994
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| 32 | ITK
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| Identification cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q.
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| Gibson S, et al.
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| Blood 82 : 1561-1572. 1993
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