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FLASH GENE
Symbol ITGA11 contributors: mct - updated : 09-02-2018
HGNC name integrin, alpha 11
HGNC id 6136
Location 15q23      Physical location : 68.594.049 - 68.724.492
Synonym symbol(s) HsT18964
DNA
TYPE functioning gene
STRUCTURE 130.45 kb     31 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • promoter has binding sites for transcriptional factors regulated by IFNs and the double-stranded RNA dependent protein kinase (PKR)
  • 3 kb alpha11 promoter contains most of the regulatory elements that direct ectomesenchymal and mesodermal fibroblast-specific expression
    • MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    31 - 5035 - 1188 - 2015 24962729
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivesalivary gland   highly
    Reproductivefemale systemuterus   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal signal peptide,with large extracellular domain consisting of a sevenfold repeated structure (FG-GAP)
  • an I domain, expressed in muscle tissue, with a metal ion-dependent adhesion site motif
  • putative cation-binding motifs in the three of four C terminal repeats
  • a single inserted between the second and third repeats ligand binding
  • a single transmembrane segment (1TM) and a short non conserved cytoplasmic domain
    • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY integrin family
    CATEGORY adhesion , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • is involved in the formation of myofibroblasts and fibroid development
  • may be involved in attaching muscle tissue to the extracellular matrix
  • decrease in ITGA11 is associated with its loss from focal adhesions
  • might be involved in fibrogenic signaling and might act downstream of the hedgehog signaling pathway
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component likely dimerizing with ITGB1
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interferon stimulated gene
  • interactions between ITGA11s and the Smad-dependent TGFB2 signalling may contribute to the formation of pro-fibrotic myofibroblasts and the development of a fibrotic interstitium in diabetic cardiomyopathy
  • glycated collagen in the cardiac interstitium triggers an autocrine TGFB2 signaling pathway that stimulates ITGA expression through Smad2/3 binding elements in the ITGA promoter, which is important for myofibroblast formation and fibrosis
  • FGF2 may be redirecting fibroblasts towards an anti-fibrotic phenotype by overriding TGFB1 mediated ITGA11 expression
    • cell & other
    REGULATION
    induced by TGFB1, inducing alpha11 transcription in the fibrosarcoma cell line HT1080 as well as in primary fibroblasts
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in non-small-cell lung carcinoma
    tumoral     --over  
    in head and neck squamous cell stroma and colocalized with ACTA2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS