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FLASH GENE
Symbol ITGA11 contributors: mct - updated : 09-02-2018
HGNC name integrin, alpha 11
HGNC id 6136
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivesalivary gland   highly
Reproductivefemale systemuterus   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal signal peptide,with large extracellular domain consisting of a sevenfold repeated structure (FG-GAP)
  • an I domain, expressed in muscle tissue, with a metal ion-dependent adhesion site motif
  • putative cation-binding motifs in the three of four C terminal repeats
  • a single inserted between the second and third repeats ligand binding
  • a single transmembrane segment (1TM) and a short non conserved cytoplasmic domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY integrin family
    CATEGORY adhesion , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • is involved in the formation of myofibroblasts and fibroid development
  • may be involved in attaching muscle tissue to the extracellular matrix
  • decrease in ITGA11 is associated with its loss from focal adhesions
  • might be involved in fibrogenic signaling and might act downstream of the hedgehog signaling pathway
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component likely dimerizing with ITGB1
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interferon stimulated gene
  • interactions between ITGA11s and the Smad-dependent TGFB2 signalling may contribute to the formation of pro-fibrotic myofibroblasts and the development of a fibrotic interstitium in diabetic cardiomyopathy
  • glycated collagen in the cardiac interstitium triggers an autocrine TGFB2 signaling pathway that stimulates ITGA expression through Smad2/3 binding elements in the ITGA promoter, which is important for myofibroblast formation and fibrosis
  • FGF2 may be redirecting fibroblasts towards an anti-fibrotic phenotype by overriding TGFB1 mediated ITGA11 expression
  • cell & other
    REGULATION
    induced by TGFB1, inducing alpha11 transcription in the fibrosarcoma cell line HT1080 as well as in primary fibroblasts
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in non-small-cell lung carcinoma
    tumoral     --over  
    in head and neck squamous cell stroma and colocalized with ACTA2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS