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FLASH GENE
Symbol IRX2 contributors: mct - updated : 20-09-2006
HGNC name iroquois homeobox 2
HGNC id 14359
Location 5p15.33      Physical location : 2.746.280 - 2.751.769
Synonym name
  • iroquois homeobox protein 2
  • likely ortholog of mouse iroquois homeobox protein 2
  • homeodomain protein IRXA2
  • iroquois-class homeodomain protein IRX-2
  • Synonym symbol(s) IRXA2
    DNA
    TYPE functioning gene
    STRUCTURE 5.49 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC389262 5 LOC389262 NKD2 5p15.3 naked cuticle homolog 2 (Drosophila) SLC12A7 5p15.3 solute carrier family 12 (potassium/chloride transporters), member 7 LOC389263 5 hypothetical gene supported by AK096096 LOC340024 5p15.33 hypothetical protein LOC340024 FLJ31236 5p15.33 hypothetical protein FLJ31236 TERT 5p15.33 telomerase reverse transcriptase CRR9 5pter-p15.3 cisplatin resistance related protein CRR9p SLC6A3 5p15.3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 FLJ12443 5p15.33 hypothetical protein FLJ12443 LOC389264 5 LOC389264 LOC340026 5p15.33 similar to succinate dehydrogenase flavoprotein subunit LOC389265 5 hypothetical gene supported by NM_174907 LOC389266 5 LOC389266 MRPL36 5p15.3 mitochondrial ribosomal protein L36 NDUFS6 5pter-p15.33 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) LOC389267 5 similar to antifreeze glycoprotein precursor - black rockcod IRX4 5p15.3 iroquois homeobox protein 4 IRX2 5p15.3 iroquois homeobox protein 2 CEI 5p15.33 CEI protein LOC391734 5 similar to 3-hydroxyisobutyryl-Coenzyme A hydrolase isoform 1 LOC389268 5 LOC389268 LOC389269 5 LOC389269 IRX1 5p15.3 iroquois homeobox protein 1
    regionally located close to IRX1 and IRX4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3070 - 471 - -
    5 - 2316 - 471 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    Respiratorylung    
    Urinarykidney    
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a homeobox DNA-binding domain
  • a hexapeptide-like motif
  • HOMOLOGY
    interspecies ortholog to murine Irx2
    homolog to C.elegans C36F7.1
    Homologene
    FAMILY
  • TALE/IRO family of homeobox proteins
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing multiple roles during pattern formation of vertebrate embryos
  • involved in epithelial cell differentiation as well as ductal and lobular proliferation of breast cells
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS