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FLASH GENE
Symbol IRX2 contributors: mct - updated : 20-09-2006
HGNC name iroquois homeobox 2
HGNC id 14359
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 3070 - 471 - -
5 - 2316 - 471 - -
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas    
Respiratorylung    
Urinarykidney    
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a homeobox DNA-binding domain
  • a hexapeptide-like motif
  • HOMOLOGY
    interspecies ortholog to murine Irx2
    homolog to C.elegans C36F7.1
    Homologene
    FAMILY
  • TALE/IRO family of homeobox proteins
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing multiple roles during pattern formation of vertebrate embryos
  • involved in epithelial cell differentiation as well as ductal and lobular proliferation of breast cells
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS