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FLASH GENE
Symbol INSM2 contributors: mct - updated : 08-01-2014
HGNC name insulinoma-associated 2
HGNC id 17539
Location 14q13.2      Physical location : 36.003.247 - 36.006.260
Synonym name insulinoma-associated protein IA-6
Synonym symbol(s) mlt1, IA-6
DNA
TYPE functioning gene
STRUCTURE 3.01 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
C14orf147 14q13.1 chromosome 14 open reading frame 147 LOC122585 14q13.1 similar to 60S ribosomal protein L23a C14orf11 14q13 chromosome 14 open reading frame 11 SNX6 14q12 sorting nexin 6 LOC390465 14 similar to 60S ribosomal protein L23a CFL2 14q12-q13 cofilin 2 (muscle) LOC387982 14 similar to 60S RIBOSOMAL PROTEIN L12 BAZ1A 14q12-q13 bromodomain adjacent to zinc finger domain, 1A LOC390466 14 similar to SMT3 suppressor of mif two 3 homolog 2 LOC338902 14q13.2 similar to Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule alpha 4) (Alpha 4 protein) SRP54 14q12-q13 signal recognition particle 54kDa C14orf24 14q13.2 chromosome 14 open reading frame 24 C14orf10 14q12 chromosome 14 open reading frame 10 KIAA0391 14q13.1-q21.2 chromosome 14 open reading frame 10 CDC10P 14 CDC10 cell division cycle 10 homolog (S. cerevisiae) pseudogene MRP63P8 14q13.2 mitochondrial ribosomal protein 63 pseudogene 8 PSMA6 14q13 proteasome (prosome, macropain) subunit, alpha type, 6 LOC122589 14q13.2 similar to 60S acidic ribosomal protein P0 (L10E) NFKBIA 14q13 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha DNAJC8P1 14 DnaJ (Hsp40) homolog, subfamily C, member 8 pseudogene 1 LOC387983 14 LOC387983 LOC390467 14 similar to 40S RIBOSOMAL PROTEIN S3A (V-FOS TRANSFORMATION EFFECTOR PROTEIN) LOC122592 14q13.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) INSM2 14q13.1 insulinoma-associated 2 LOC387984 14 similar to GARNL1 protein GARNL1 14q13.2 GTPase activating RANGAP domain-like 1 LOC341835 14q13.2 similar to glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 NUTF2P2 14 nuclear transport factor 2 pseudogene 2 BRMS1L 14q13.2 breast cancer metastasis-suppressor 1-like LOC390468 14 similar to Plasmodium falciparum trophozoite antigen r45-like protein LOC390469 14 similar to interleukin enhancer binding factor 2 MBIP 14q13 similar to interleukin enhancer binding factor 2 LOC387985 14 hypothetical gene supported by AY102071 TITF1 14q13.1-q13.2 thyroid transcription factor 1 PHKBP2 14q13.2 phosphorylase kinase, beta pseudogene 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 3024 - 566 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
five C2H2-type zinc fingers
HOMOLOGY
interspecies homolog to murine Insm2
Homologene
FAMILY
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION may be associated with the transformation of neuroendocrine cells
CELLULAR PROCESS nucleotide, transcription
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA binding
RNA
small molecule metal binding,
Zn2+
protein
  • INSM2 plays potentially an important role in the differentiation cascade of NEUROG3/NEUROD1 signaling in pancreatic islets
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS