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FLASH GENE
Symbol INHBA contributors: - updated : 23-09-2004
HGNC name inhibin, beta A (activin A, activin AB alpha polypeptide)
HGNC id 6066
Location 7p15-p13      Physical location : 41.728.602 - 41.742.706
Synonym name
  • erythroid differentiation factor
  • follicle-stimulating hormone-releasing protein
    • Synonym symbol(s) EDF, FRP
    DNA
    TYPE functioning gene
    STRUCTURE 13.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
    endocrinebraindiencephalonpituitary  
    Endocrinepancreas    
    Nervousspinal cord    
    Reproductivefemale systemovary   
     male systemtestis   
     male systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Nervouscentral   
    cell lineage erythroid
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    mono polymer homomer , heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine Inhba
    homolog to C.elegans B0412.2
    Homologene
    FAMILY
  • TGFB superfamily member
  • BMP family
    • CATEGORY signaling hormone growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • inhibiting secretion of pituitary follicle-stimulating hormone
  • involved in embryonic axis development
  • regulating negatively gonadal stromal cell proliferation
  • having tumour-suppressor activity
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    text
  • erythroid
  • skeletal development
    • PATHWAY
    metabolism
    signaling hormonal
    FSH releasing protein
    a component
  • homodimerizing to form activin A stimulator of FSH secretion and involved in embryonic axis development
  • heterodimerizing with INHBB or INHA to form activin AB or inhibin A,respectively
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mice Inhba -/- demonstrate dysruption of whisker,palate,tooth development