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FLASH GENE
Symbol INHBA contributors: - updated : 23-09-2004
HGNC name inhibin, beta A (activin A, activin AB alpha polypeptide)
HGNC id 6066
DNA
TYPE functioning gene
STRUCTURE 13.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
endocrinebraindiencephalonpituitary  
Endocrinepancreas    
Nervousspinal cord    
Reproductivefemale systemovary   
 male systemtestis   
 male systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Nervouscentral   
cell lineage erythroid
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
mono polymer homomer , heteromer , dimer
isoforms Precursor
HOMOLOGY
interspecies ortholog to murine Inhba
homolog to C.elegans B0412.2
Homologene
FAMILY
  • TGFB superfamily member
  • BMP family
  • CATEGORY signaling hormone growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • inhibiting secretion of pituitary follicle-stimulating hormone
  • involved in embryonic axis development
  • regulating negatively gonadal stromal cell proliferation
  • having tumour-suppressor activity
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    text
  • erythroid
  • skeletal development
  • PATHWAY
    metabolism
    signaling hormonal
    FSH releasing protein
    a component
  • homodimerizing to form activin A stimulator of FSH secretion and involved in embryonic axis development
  • heterodimerizing with INHBB or INHA to form activin AB or inhibin A,respectively
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mice Inhba -/- demonstrate dysruption of whisker,palate,tooth development