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FLASH GENE

Symbol

IMPDH2

contributors: mct - updated : 20-04-2015

HGNC name	IMP (inosine monophosphate) dehydrogenase 2
HGNC id	6053

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p21.2      Physical location : 49.061.766 - 49.066.875
Synonym symbol(s)	IMPD2
EC.number	1.1.1.205

DNA

TYPE	functioning gene
STRUCTURE	5.12 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000884 14 - 1712 - 514 - 1995 7763314

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic progenitor cell Homo sapiens Lymphoid/Immune lymphocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two CBS forming a stable globular domain

mono polymer

homomer , tetramer

HOMOLOGY

intraspecies

paralog to IMPDH1

Homologene

FAMILY

IMPDH/GMPR family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	involved in the regulation of cell growth and in the development of malignancy and the growth progression of some tumors
	important target for the development of drugs with both chemotherapeutic and immunosuppressive activity
	rate-limiting enzyme in the de novo guanine nucleotide biosynthesis and linked to cell growth, differentiation, and malignant transformation
	directly involved in the development of chemoresistance in osteosarcoma cells
	essential for lymphocyte proliferation
	plays an important role in the negative regulation of TLR2 signaling by modulating PI3K activity
	increases the phosphatase activity of PTPN6, which participates to the inactivation of PI3K
	recruited to a TLR2-dependent membrane activation cluster within the lipid rafts after stimulation with lipopeptides
	novel negative regulator of NFKB activation that contributes to the dephosphorylation of the RELA subunit of PI3K through increased PTPN6 activity
	CTPS1 and IMPDH2, are key enzymes in CTP and GTP biosynthesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

ANKRD9 facilitates degradation of inosine monophosphate dehydrogenase 2 (IMPDH2), the rate-limiting enzyme in GTP biosynthesis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in osteosarcoma patients with poor response to chemotherapy

Susceptibility

to resistance to immunosuppressive drug, mycophenolic acid (MPA)

Variant & Polymorphism SNP	increasing the risk of resistance to immunosuppressive drug, mycophenolic acid (MPA)(

Candidate gene
Marker	may be a protein biomarker in colorectal cancer (
Therapy target
	System Type Disorder Pubmed cancer bone   targeting of IMPDH2 by RNAi or more effective pharmacological inhibitors in combination with chemotherapy might be a promising means of overcoming chemoresistance in osteosarcomas with high IMPDH2 expression cancer digestive colon novel therapeutic target in colorectal cancer

ANIMAL & CELL MODELS