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FLASH GENE
Symbol IMPDH2 contributors: mct - updated : 20-04-2015
HGNC name IMP (inosine monophosphate) dehydrogenase 2
HGNC id 6053
Location 3p21.2      Physical location : 49.061.766 - 49.066.875
Synonym symbol(s) IMPD2
EC.number 1.1.1.205
DNA
TYPE functioning gene
STRUCTURE 5.12 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 1712 - 514 - 1995 7763314
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticprogenitor cell Homo sapiens
Lymphoid/Immunelymphocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two CBS forming a stable globular domain
mono polymer homomer , tetramer
HOMOLOGY
intraspecies paralog to IMPDH1
Homologene
FAMILY IMPDH/GMPR family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • involved in the regulation of cell growth and in the development of malignancy and the growth progression of some tumors
  • important target for the development of drugs with both chemotherapeutic and immunosuppressive activity
  • rate-limiting enzyme in the de novo guanine nucleotide biosynthesis and linked to cell growth, differentiation, and malignant transformation
  • directly involved in the development of chemoresistance in osteosarcoma cells
  • essential for lymphocyte proliferation
  • plays an important role in the negative regulation of TLR2 signaling by modulating PI3K activity
  • increases the phosphatase activity of PTPN6, which participates to the inactivation of PI3K
  • recruited to a TLR2-dependent membrane activation cluster within the lipid rafts after stimulation with lipopeptides
  • novel negative regulator of NFKB activation that contributes to the dephosphorylation of the RELA subunit of PI3K through increased PTPN6 activity
  • CTPS1 and IMPDH2, are key enzymes in CTP and GTP biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ANKRD9 facilitates degradation of inosine monophosphate dehydrogenase 2 (IMPDH2), the rate-limiting enzyme in GTP biosynthesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in osteosarcoma patients with poor response to chemotherapy
    Susceptibility to resistance to immunosuppressive drug, mycophenolic acid (MPA)
    Variant & Polymorphism SNP increasing the risk of resistance to immunosuppressive drug, mycophenolic acid (MPA)(
    Candidate gene
    Marker
  • may be a protein biomarker in colorectal cancer (
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbone 
    targeting of IMPDH2 by RNAi or more effective pharmacological inhibitors in combination with chemotherapy might be a promising means of overcoming chemoresistance in osteosarcomas with high IMPDH2 expression
    cancerdigestivecolon
    novel therapeutic target in colorectal cancer
    ANIMAL & CELL MODELS