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FLASH GENE
Symbol IL8 contributors: mct - updated : 27-10-2011
HGNC name interleukin 8
HGNC id 6025
Location 4q13.3      Physical location : 74.606.274 - 74.609.431
Synonym name
  • chemokine (C-X-C motif) ligand 8
  • neutrophils activating peptide 1
  • emoctakin
  • granulocyte chemotactic protein 1
  • monocyte-derived neutrophil-activating peptide
  • beta-thromboglobulin-like protein
  • small inducible cytokine subfamily B, member 8
  • Synonym symbol(s) K60, LECT, LUCT, CXCL8, GCP-1, GCP1, LYNAP, IL-8, MDNCF, MONAP, NAP-1, NAP1, SCYB8, TSG-1, AMCF-I, b-ENAP, NAF, 3-10C
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 3.16 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - IL8 - CXCL1 / PPBP / PF4 - CXCL5 / CXCL6 - CXCL2 / CXCL3 - CXCL11 - CXCL10 - CXCL9 - qter
    Authors O'Donovan et al. (99)
    Physical map
    FLJ38991 4q21.1 hypothetical protein FLJ38991 ANKRD17 4q13.3 ankyrin repeat domain 17 HMGA1L2 4q21.1 high mobility group AT-hook 1-like 2 ALB 4q11-q13 albumin AFP 4q11-q13 alpha-fetoprotein AFM 4q11-q13 afamin RASSF6 4q21.21 Ras association (RalGDS/AF-6) domain family 6 IL8 4q13-q21 interleukin 8 CXCL6 4q21 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) PF4V1 4q13-q21 platelet factor 4 variant 1 CXCL1 4q21 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) CXCL1P 4q21.21 chemokine (C-X-C motif) ligand 1 pseudogene PF4 4q13-q21 platelet factor 4 (chemokine (C-X-C motif) ligand 4) PPBP 4q12-q13 pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) CXCL5 4q13-q21 chemokine (C-X-C motif) ligand 5 CXCL3 4q21 chemokine (C-X-C motif) ligand 3 SPBPBP 4q21.21 DNA-binding protein amplifying expression of surfactant protein B CXCL2 4q21 chemokine (C-X-C motif) ligand 2 LOC255324 4q21.21 similar to ALGV3072 EREG 4q25-q26 epiregulin AREG 4q13-q21 amphiregulin (schwannoma-derived growth factor)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1666 - 99 - - 9828130
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Endocrinepancreas   highly
    Reproductivemale systemprostate  lowly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoietic   highly
    Epithelialbarrier/liningepidermis  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    Reproductiveepithelial cell
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • intercrine alpha (chemokine CxC) family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • neutrophil activating peptide 1, monocyte-derived neutrophil chemotactic factor
  • involved in the benign prostatic hyperplasia
  • functioningas a chemoattractant, and is also a potent angiogenic factor
  • potential role of IL8 to determine the fate of other inflammatory molecules, such as IL18, within the inflammatory milieu of the cystic fibrosis lung
  • chemokine with a defining CXC amino acid motif, known to possess tumorigenic and proangiogenic properties
  • signaling role for lactate in endothelial cells and they identify the lactate/NFkappaB/IL8 pathway as an important link between tumor metabolism and angiogenesis
  • essential role of IL8 signaling for the acquisition and/or maintenance of the mesenchymal and invasive features of Brachyury-overexpressing tumor cells
  • IL8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells
  • plays a neuroprotective role in the AD pathogenesis probably by modulating neuronal functions
  • protects neurons through an autocrine mechanism and that it induces the synthesis and/or release of neurotrophic factors
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • N- and C-terminal peptides of IL8 are ligands for IL8RA and IL8RB
  • interacting with DEFA1 (DEFA1 mainly enhanced the expression of IL8 in epithelial cells, whereas it enhanced transforming growth factor-beta and vascular endothelial growth factor expressions in lung fibroblasts)
  • TMED1 is required for optimal IL33-induced IL8 and IL6 production
  • cell & other
    REGULATION
    induced by Prokineticin 1 (induces CCL4, CXCL1 and IL8 in monocytes but not in macrophages and dendritic cells) (Monnier 2008)
    ENTPD1 (inhibition of ENTPD1 markedly increases IL8 production by TLR-stimulated human neutrophils)
    neurotoxins such as Abeta, as well as pro-inflammatory cytokines such as TNF, inducing CXCL8 production in neurons and Abeta and/or IL1B in glial cells
    repressed by oestradiol
    Other SNAI1 activated the expression of IL8 by direct binding to its E3/E4 E-boxes (
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in ulcerative colitis and Crohn's disease and in osteoarthritis cartilage
    tumoral     --over  
    in mesothelioma
    tumoral     --over  
    colorectal cancer (CRC), and is associated with poor prognosis
    constitutional     --over  
    significantly higher IL8 levels in Alzheimer disease brain tissue lysates as compared to those of age-matched controls
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    important therapeutic target in colorectal cancer
    ANIMAL & CELL MODELS