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FLASH GENE
Symbol IL5 contributors: npt/ - updated : 10-08-2007
HGNC name interleukin 5 (colony-stimulating factor, eosinophil)
HGNC id 6016
Location 5q31.1      Physical location : 131.877.135 - 131.879.214
Synonym name
  • T-cell replacing factor
  • eosinophil differentiation factor
  • B cell differentiation factor I
  • Synonym symbol(s) E-CSF, EDF, TRF, IL-5
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 2.08 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure the coordinate regulator (LCR) of IL4, IL3 and IL5 is A 0.4kb sequence which is located in the intergenic region between IL4 and IL13 (Loots 00)
    MAPPING cloned Y linked N status confirmed
    Map see IRF1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 816 13.1 134 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Il5
    ortholog to C.elegans f45g2.8
    Homologene
    FAMILY interleukin (IL-5) family
    CATEGORY immunity/defense , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • colony-stimulating factor (eosinophil and basophil lineages)
  • inducing terminal differentiation of B cells to immunoglobulin secreting cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS