Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IL5 contributors: mct - updated : 08-02-2023
HGNC name interleukin 5 (colony-stimulating factor, eosinophil)
HGNC id 6016
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to murine Il5
ortholog to C.elegans f45g2.8
Homologene
FAMILY interleukin (IL-5) family
CATEGORY immunity/defense , signaling cytokine
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • colony-stimulating factor (eosinophil and basophil lineages)
  • inducing terminal differentiation of B cells to immunoglobulin secreting cells
  • IL5 is a T helper 2 cytokine important in the trafficking and survival of eosinophils
  • IL5 was found to be responsible for recruitment of eosinophils and tumor-promoting myeloid suppressor cells to malignant pleural effusions (MPE)
  • exerts a central pathogenic role in differentiation, recruitment, survival, and degranulation of eosinophils
  • IL8, IL6, IL5 might likely play central roles in cytokine storms associated with COVID-19
  • IL5 facilitates the recovery of cardiac dysfunction post- myocardial infarction (MI) by promoting eosinophils (EOS) accumulation and subsequent CD206+ macrophage polarization via the IL-4/STAT6 axis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • macrophage IL5 is a target gene for NR1H3 activation, and the induction of macrophage IL5 expression can be related to NR1H3-inhibited atherosclerosis
  • IL4 cooperates likely with IL5 to promote eosinophil differentiation
  • IL5 suppresses vascular endothelial growth factor-induced angiogenesis through STAT5 signaling
  • MARCHF2 and MARCHF3 are critical negative regulators of IL5-triggered signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    dysregulation of IL5 production in peripheral blood mononuclear cells (PBMC) in familial eosinophilia (FE)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • the early detection of multiple plasma cytokines might help to predict the prognosis of COVID-19
  • Therapy target
    SystemTypeDisorderPubmed
    allergyasthm 
    is a suitable target for add-on biological therapies based on IL5 inhibition for patients with severe type 2 (T2)-high eosinophilic asthma, refractory to conventional anti-inflammatory drugs
    ANIMAL & CELL MODELS