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FLASH GENE
Symbol IL2 contributors: mct/npt/pgu - updated : 24-10-2017
HGNC name interleukin 2
HGNC id 6001
Corresponding disease
IL2 immunodeficiency, severe, combined
Location 4q27      Physical location : 123.372.629 - 123.377.650
Synonym name
  • aldesleukin
  • T cell growth factor
  • involved in regulation of T-cell clonal expansion T cell growth factor
  • lymphokine
  • Synonym symbol(s) TCGF, IL-2
    DNA
    TYPE functioning gene
    STRUCTURE 5.03 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   enhancer
    text structure
  • important regulatory sequences in the IL2 promoter are bound by FOXK2 and this binding may be involved in the control of IL2 gene expression
  • CD28-responsive element/activator protein-1-binding site (RE/AP), functional target for MAP3K7
  • An enhancer element (CD28RE) specifically responsive to CD28 signals
  • MAPPING cloned Y linked N status confirmed
    Physical map
    LOC201989 4q27 similar to Glycerol kinase, testis specific 1 (ATP:glycerol 3-phosphotransferase) (Glycerokinase) (GK) LOC389221 4 similar to hypothetical protein LOC349114 LOC389222 4 LOC389222 LOC152972 4q27 similar to bA291L22.2 (similar to CDC10 (cell division cycle 10, S. cerevisiae, homolog)) PDE5A 4q26 phosphodiesterase 5A, cGMP-specific LOC391691 4 similar to ARHGAP20 protein MAD2L1 4q27 MAD2 mitotic arrest deficient-like 1 (yeast) LOC344988 4q27 similar to GTP-binding protein SAR1a (COPII-associated small GTPase) PRDM5 4q27 PR domain containing 5 FLJ23191 4q27 hypothetical protein FLJ23191 TNIP3 4q27 TNFAIP3 interacting protein 3 GPR103 4q27 G protein-coupled receptor 103 LOC391692 4 similar to TUBULIN BETA CHAIN ANXA5 4q26-q27 annexin A5 FLJ30834 4q27 hypothetical protein FLJ30834 PMSCL1 4q27 polymyositis/scleroderma autoantigen 1, 75kDa CCNA2 4q27 cyclin A2 BBS7 4q27 Bardet-Biedl syndrome 7 TRPC3 4q25-q27 transient receptor potential cation channel, subfamily C, member 3 KIAA1109 4q28.1 hypothetical protein KIAA1109 Tenr 4q28.1 testis nuclear RNA-binding protein IL2 4q26-q27 interleukin 2 IL21 4q26-q27 interleukin 21 FLJ35630 4q28.1 hypothetical protein FLJ35630 FGF2 4q26 fibroblast growth factor 2 (basic) NUDT6 4q26 nudix (nucleoside diphosphate linked moiety X)-type motif 6 SPATA5 4q27 spermatogenesis associated 5 SPRY1 4q26-q27 sprouty homolog 1, antagonist of FGF signaling (Drosophila) LOC391693 4 similar to ribosomal protein L21 LOC391694 4 similar to Peptidylprolyl isomerase A (cyclophilin A) LOC391695 4 similar to Tubulin alpha-4 chain (Alpha-tubulin 4) LOC391696 4 similar to Synaptic glycoprotein SC2 KIAA1223 4q28.1 KIAA1223 protein LOC339951 4q28.1 similar to ENSANGP00000007226
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 822 - 153 - 1992 1394441
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Il2
    ortholog to murine Il2
    Homologene
    FAMILY
  • interleukin (IL-2) family
  • CATEGORY protooncogene , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • required for T-cell proliferation and other activities crucial to regulation of the immune response
  • can stimulate B cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells
  • involved in regulatory T cell function and imbalance in normal immune physiology causes autoimmunity
  • development of Ag-specific IL2-producing memory T cells appears to be essential for the development of IgG-secreting plasma cells
  • unique role for IL2, in promoting the differentiation not only of primary effector CD8+ T cells, but also of CD8+ memory T cells capable of secondary effector differentiation
  • IL2 and CSF2 are regulated by DNA demethylation during activation of T cells, B cells and macrophages
  • plays a central role during the priming and differentiation of T cells
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • T cell differentiation
  • positive regulation of cell proliferation
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PRDM1 is a transcription repressor that is known to negatively regulate the expression of IL2
  • IRF4 activates IL2 and IL4 promoters in cooperation with REL
  • DUSP4 suppresses CD4(+) T-cell proliferation through novel regulations in STAT5B phosphorylation and IL2 signaling
  • IL2 upregulates CD86 expression on human CD4(+) and CD8(+) T cells via a receptor-dependent mechanism that involves the NFATC1 and mammalian target of rapamycin pathways
  • nuclear activation of REL not only regulates the initiation of CSF2 and IL2 gene activation in response to T cell activation, but also the termination of these gene responses following the removal of the activating signal
  • a tight balance between IL2 and the effector cytokine IL17A is essential for immune homeostasis
  • CREM mediates epigenetic remodeling of the IL2 and IL17A gene during T-cell differentiation in favor of effector memory T cells in health and disease
  • NFKB1 controls IL2 and CSF2 expression during T cell development and activation process
  • ETS1 promotes the expression of IL2 by nuclear factor of activated T-cells (NFATC1)-dependent mechanisms
  • cell & other
    REGULATION
    activated by JUNB, a transcriptional activator of various cytokine genes, such as IL2, IL4, and IL10
    Other produced in response to antigenic or mitogenic stimulation
    ASSOCIATED DISORDERS
    corresponding disease(s) IL2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    correlates with reduced function of CD4+ CD25+ regulatory T cells, which are critical for maintaining immune homeostasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS