protein
| PRDM1 is a transcription repressor that is known to negatively regulate the expression of IL2 |
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IRF4 activates IL2 and IL4 promoters in cooperation with REL |
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DUSP4 suppresses CD4(+) T-cell proliferation through novel regulations in STAT5B phosphorylation and IL2 signaling |
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IL2 upregulates CD86 expression on human CD4(+) and CD8(+) T cells via a receptor-dependent mechanism that involves the NFATC1 and mammalian target of rapamycin pathways |
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nuclear activation of REL not only regulates the initiation of CSF2 and IL2 gene activation in response to T cell activation, but also the termination of these gene responses following the removal of the activating signal |
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a tight balance between IL2 and the effector cytokine IL17A is essential for immune homeostasis |
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CREM mediates epigenetic remodeling of the IL2 and IL17A gene during T-cell differentiation in favor of effector memory T cells in health and disease |
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NFKB1 controls IL2 and CSF2 expression during T cell development and activation process |
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ETS1 promotes the expression of IL2 by nuclear factor of activated T-cells (NFATC1)-dependent mechanisms |
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IFNA1 mediates inhibition of IL7- or IL2-induced T cell proliferation |