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FLASH GENE
Symbol IL1RN contributors: mct - updated : 02-06-2015
HGNC name interleukin 1 receptor antagonist
HGNC id 6000
Location 2q14.2      Physical location : 113.875.469 - 113.891.592
Synonym name
  • intracellular interleukin-1 receptor antagonist (icIL-1ra)
  • type II interleukin-1 receptor antagonist
  • Synonym symbol(s) IL1RA, ICIL-1RA, IL1F3, IL1X
    DNA
    TYPE like-sequence
    SPECIAL FEATURE component of a cluster
    STRUCTURE 16.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - D2S25 - PAFAH1P2 - D2S1896 - D2S2672 - D2S160 - D2S1838 - SLC20A1 - D2S2728 - D2S2625 - D2S1820 - IL1A - IL1B - IL1F7 - IL1F9 - IL1F6 - IL1F8 - IL1F5 - IL1F10 - IL1RN - PAX8 PAX8 - LCO - D2S43 - D2S54 - D2S44 - qter
    Authors Steinkasserer (92),Nicklin (94),Nothwang (97),Nicklin(02)
    Physical map
    FLJ14681 2q13 hypothetical protein FLJ14681 FLJ37440 2q13 hypothetical protein FLJ37440 LOC84524 2q13 zinc finger protein FLJ41410 2q13 FLJ41410 protein LOC389020 2 similar to RAN-binding protein 2-like 1 isoform 1; sperm membrane protein BS-63; RAN-binding protein 2-like 1 TTL 2q13 similar to RAN-binding protein 2-like 1 isoform 1; sperm membrane protein BS-63; RAN-binding protein 2-like 1 POLR1B 2q13 polymerase (RNA)1polypeptide B, 128kDa C2orf9 2q13 chromosome 2 open reading frame 9 SLC20A1 2q11-q14 solute carrier family 20 (phosphate transporter), member 1 FLJ40629 2q14.1 hypothetical protein FLJ40629 IL1A 2q13 interleukin 1, alpha IL1B 2q13 interleukin 1, beta IL1F7 2q12.1-q14.1 interleukin 1 family, member 7 (zeta) IL1F9 2q13 interleukin 1 family, member 9 IL1F6 2q12-q14.1 interleukin 1 family, member 6 (epsilon) IL1F8 2q12-q14.1 interleukin 1 family, member 8 (eta) IL1F5 2q12.1 interleukin 1 family, member 5 (delta) IL1F10 2q12 interleukin 1 family, member 10 (theta) IL1RN 2q13-q14.2 interleukin 1 receptor antagonist TIC 2q13 interleukin 1 receptor antagonist PAX8 2q12-q14 paired box gene 8 LOC391427 2 similar to Ig kappa chain precursor V region (orphon V108) - human  (fragment) CBWD2 2q13 COBW domain containing 2 FOXD4L1 2q13 COBW domain containing 2 LOC284964 2q14.1 similar to bA395L14.5 (novel phosphoglucomutase like protein) LOC389021 2 hypothetical gene supported by BC063555 MGC13005 2q14.1 hypothetical protein MGC13005 RPL23AP7 2q14 ribosomal protein L23a pseudogene 7 RABL2A 2q13 RAB, member of RAS oncogene family-like 2A bA395L14.12 2q14.1 u2 small nuclear ribonucleoprotein polypeptide A' pseudogene bA395L14.13 2q14.1 acrosin-like protease SLC35F5 2q14.1 solute carrier family 35, member F5 ACTR3 2q13 ARP3 actin-related protein 3 homolog (yeast) LOC284968 2q14.1 hypothetical LOC284968
    RNA
    TRANSCRIPTS type messenger
    text with a secreted form and an alternatively spliced intracellular form
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1760 - 177 - Rholeder
    - - 1865 - 180 - Rholeder
    - - 1802
    - - 1973 - 143 - Rholeder
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Cardiovascularheart   highly
    Digestiveliver   moderately
    Endocrinepancreas   highly
    Nervousbrain   moderately
    Respiratorylung   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY IL-1 family
    CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    basic FUNCTION interleukin 1,receptor antagonist
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to ankylosing spondylitis
  • to Chronic kidney disease (CKD) and periodontitis (PD)
  • Variant & Polymorphism other
  • allele 2 of a VNTR increasing the risk of ankylosing spondylitis
  • association of IL1RN alleles with susceptibility to CKD and PD
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS