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FLASH GENE
Symbol IL1RN contributors: mct - updated : 02-06-2015
HGNC name interleukin 1 receptor antagonist
HGNC id 6000
RNA
TRANSCRIPTS type messenger
text with a secreted form and an alternatively spliced intracellular form
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1760 - 177 - Rholeder
- - 1865 - 180 - Rholeder
- - 1802
- - 1973 - 143 - Rholeder
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Cardiovascularheart   highly
Digestiveliver   moderately
Endocrinepancreas   highly
Nervousbrain   moderately
Respiratorylung   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY IL-1 family
CATEGORY signaling cytokine , receptor
SUBCELLULAR LOCALIZATION extracellular
    intracellular
basic FUNCTION interleukin 1,receptor antagonist
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
  • to ankylosing spondylitis
  • to Chronic kidney disease (CKD) and periodontitis (PD)
  • Variant & Polymorphism other
  • allele 2 of a VNTR increasing the risk of ankylosing spondylitis
  • association of IL1RN alleles with susceptibility to CKD and PD
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS