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FLASH GENE
Symbol IL11 contributors: mct/pgu - updated : 03-01-2012
HGNC name interleukin 11
HGNC id 5966
Location 19q13.42      Physical location : 55.875.756 - 55.881.814
Synonym name
  • adipogenesis inhibitory factor
  • oprelvekin
  • Synonym symbol(s) AGIF, MGC2146, IL-11
    DNA
    TYPE functioning gene
    STRUCTURE 6.06 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D19S504 - D19S866 - KLK1 - D19S206 - D19S601 - D19S571 - D19S180 - D19S589 - IL11 - qter
    Physical map
    NALP2 19q13.42 HSPC189 protein GP6 19q13.4 glycoprotein VI (platelet) RDH13 19q13.42 retinol dehydrogenase 13 (all-trans and 9-cis) EPS8L1 19q13.42 EPS8-like 1 PPP1R12C 19q13.42 protein phosphatase 1, regulatory (inhibitor) subunit 12C TNNT1 19q13.4 troponin T1, skeletal, slow TNNI3 19q13.4 troponin I, cardiac LOC352909 19q13.4 similar to hypothetical testis protein from macaque SYT5 19q13.4 synaptotagmin V PTPRH 19q13.4 protein tyrosine phosphatase, receptor type, H LOC388563 19 LOC388563 MGC30208 19q13.42 hypothetical protein MGC30208 KIAA1115 19q13.42 KIAA1115 HSPBP1 19q13.42 hsp70-interacting protein KIAA1811 19q13.4 KIAA1811 protein LOC284417 19q13.42 similar to BC022651 protein MGC2705 19q13.42 hypothetical protein MGC2705 COXVIB2 19q13.42 cytochrome c oxidase subunit VIb, testes-specific MGC35045 19q13.42 hypothetical protein MGC35045 IL11 19q13.4 interleukin 11 MDAC1 19q13.42 MDAC1 LOC388564 19 hypothetical gene supported by BC052596 RPL28 19q13.4 ribosomal protein L28 E2-EPF LOC284296 19q13.42 hypothetical protein LOC284296 FLJ23469 19q13.42 hypothetical protein FLJ23469 LOC89887 19q13.43 hypothetical protein LOC89887 KLP1 19q13.43 K562 cell-derived leucine-zipper-like protein 1 LOC390975 19 similar to protein kinase Bsk146 FLJ35453 19q13.43 hypothetical protein FLJ35453 FLJ14768 19q13.43 hypothetical protein FLJ14768 MGC23143 LOC388565 19 similar to zinc finger protein 111 LOC147808 19q13.43 similar to zinc finger protein; zinc finger protein Zec; cDNA sequence AF435832 LOC51157 19q13.43 LDL induced EC protein HSPC189 19q13.43 HSPC189 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2354 - 199 - 2005 15940362
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  predominantly
    Reproductivefemale systemuterus    Homo sapiens
    Skin/Tegumentskin   highly
    Visualeyeretina    Homo sapiens
     eyeanterior segmentcornea   Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningendometrium highly Homo sapiens
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an extracellular region with a 2-domain structure
  • an immunoglobulin-like domain
  • a cytokine receptor-like domain
  • secondary structure
  • a conserved core motif consisting of four alpha-helices
  • HOMOLOGY
    interspecies ortholog to murine Il11
    intraspecies homolog to ciliary neurotrophic factor
    Homologene
    FAMILY
  • interleukin-6 cytokine family
  • gp130 family of cytokines
  • long-helix cytokine superfamily
  • CATEGORY signaling cytokine growth factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • stimulating the proliferation of B cells, T cell dependent
  • directly stimulating the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells
  • inducing megakaryocyte maturation resulting in increased platelet production
  • might be important as an anti-inflammatory response in the pathogenesis of intestinal inflammation
  • IL11/IL11RA pathway plays an important role in the progression and the differentiation of human gastric carcinomas
  • IL11 signaling is clearly required for normal bone turnover and normal trabecular bone mass, yet not for the effects of estradiol or estrogen deficiency on the skeleton
  • inhibits EVT (extravillous trophoblast) invasion via STAT3, indicating a likely role for IL11 in the decidual restraint of EVT invasion during normal pregnancy
  • playing a role via STAT3 and SOCS3 in initiating and progressing decidualization, and regulating human endometrial stromal cell differentiation
  • regulates inflammatory demyelination via a unique combination of immunoregulation and neuroprotection
  • with LIF regulated endometrial epithelial cell adhesion
  • cytokine with pleiotropic activities, including gestational effects
  • has roles in hematopoiesis, immune responses, the nervous system and bone metabolism
  • IL11 signaling is essential for the normal development of craniofacial bones and teeth and that its function is to restrict suture fusion and tooth number
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MSX2, RUNX2 and SMADl transcription factors appear to be key regulators of IL11 effects on IBSP transcription
  • cell & other
    REGULATION
    activated by IL13 (is a potent stimulator of IL11 and IL1RA)
    repressed by IFNG (IFN-gamma is a physiological inhibitor of IL11 expression)
    Other PROK1-PROKR1 signalling pathway regulating IL11
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    with HGF, in polycythemia vera (PV)
    constitutional     --over  
    in retina and cornea cells
    constitutional     --over  
    enhances canonical Wnt signal at least in part via a reduction in DKK2 expression to stimulate osteoblast differentiation
    tumoral     --over  
    in the endometrial tumour epithelial cells from Grade 1 and 3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • IL11 in uterine washings may be useful as a diagnostic marker for early stage endometrial cancer
  • Therapy target
    SystemTypeDisorderPubmed
    osteoarticularbone 
    possibility of modulation of IL11 signaling for the treatment of craniosynostosis
    cancerhemopathy 
    blocking the MET/HGF/IL11 pathways could be of interest as an additional therapeutic option in polycythemia vera
    immunologyautoimmunemultiple sclerosis
    IL-11 signaling may represent a therapeutic avenue to restrict CNS inflammation and potentiate oligodendrocyte survival in autoimmune demyelinating disease
    ANIMAL & CELL MODELS