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FLASH GENE
Symbol IL10RA contributors: mct - updated : 17-11-2012
HGNC name interleukin 10 receptor, alpha
HGNC id 5964
Location 11q23.3      Physical location : 117.857.105 - 117.872.196
Synonym name
  • interleukin-10 receptor alpha chain
  • interleukin-10 receptor subunit 1
  • Synonym symbol(s) CDW210A, HIL-10R, IL-10R1, CD210, CD210a
    DNA
    TYPE functioning gene
    STRUCTURE 15.09 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    TAGLN 11q23.2 transgelin PCSK7 11q23 proprotein convertase subtilisin/kexin type 7 DKFZp547C195 11q23.3 hypothetical protein DKFZp547C195 BACE 11q23.2-q23.3 beta-site APP-cleaving enzyme KIAA1052 11q23.3 KIAA1052 protein DSCAML1 11q23 Down syndrome cell adhesion molecule like 1 FXYD2 11q23,3 FXYD domain containing ion transport regulator 2 FXYD6 11q23.3 FXYD domain containing ion transport regulator 6 MSP 11q23 mosaic serine protease IL10RA 11q23.3 interleukin 10 receptor, alpha TMPRSS4 11q23.3 transmembrane protease, serine 4 SCN4B 11q23.3 sodium channel, voltage-gated, type IV, beta SCN2B 11q23 sodium channel, voltage-gated, type II, beta AMICA 11q23.3 adhesion molecule AMICA LOC196264 11q23.3 hypothetical protein LOC196264 EVA1 11q24 epithelial V-like antigen 1 CD3E 11q23.3 CD3E antigen, epsilon polypeptide (TiT3 complex) LOC390254 11 similar to carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5; N-acetylglucosamine 6-O-sulfotransferase; I-GLCNAC-6-ST CD3D 11q23.3 CD3D antigen, delta polypeptide (TiT3 complex) CD3G 11q23.3 CD3G antigen, gamma polypeptide (TiT3 complex) UBE4A 11q23.3 ubiquitination factor E4A (UFD2 homolog, yeast) ATP5L 3q27 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g MGC13053 11q23.3 hypothetical protein MGC13053 MLL 11q23 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) FLJ11783 11q23.3 hypothetical protein FLJ11783 LOC143941 11q23.3 similar to CDNA sequence BC021608 FLJ14399 11q23.3 hypothetical protein FLJ14399 FLJ21827 11q23.3 hypothetical protein FLJ21827 ARCN1 11q23.3 archain 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3672 - 578 - 1997 9271637
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     spleen   highly
    cell lineage hemopoietic cells
    cell lines cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved WSXWS motif
  • HOMOLOGY
    Homologene
    FAMILY type II cytokine receptor family
    CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text type I membrane protein
    basic FUNCTION
  • promoting survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway
  • involved in tyrosine phosphorylation of JAK1 and TYK2 kinases, by activation of this receptor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in the context of disease, responsiveness of human neutrophils to IL10 is strictly dependent upon the modulation of IL10RA expression
  • IL10 initiates potent anti-inflammatory effects via activating its cell surface receptor, composed of IL10RA and IL10RB subunits
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation     loss of function
    loss of function mutations in interleukin-10 (IL10) and interleukin-10 receptors (IL10R) cause severe infantile (very early onset) inflammatory bowel disease (IBD)
    constitutional germinal mutation      
    in patients with early-onset enterocolitis, involving hyperinflammatory immune responses in the intestine
    Susceptibility
  • to schizophrenia
  • rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)
  • Variant & Polymorphism other
  • homozygosity of the IL-10R1 G330R allele is associated with schizophrenia
  • IL10RA G330R may possibly contribute to RA or SLE disease susceptibility
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • inactivation of the Il10 receptor (Il10ra) gene in mice leads to an increased susceptibility to chemically induced colitis as in the classical Il10-deficient mutant