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FLASH GENE
Symbol IL10RA contributors: mct - updated : 17-11-2012
HGNC name interleukin 10 receptor, alpha
HGNC id 5964
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved WSXWS motif
  • HOMOLOGY
    Homologene
    FAMILY type II cytokine receptor family
    CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text type I membrane protein
    basic FUNCTION
  • promoting survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway
  • involved in tyrosine phosphorylation of JAK1 and TYK2 kinases, by activation of this receptor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in the context of disease, responsiveness of human neutrophils to IL10 is strictly dependent upon the modulation of IL10RA expression
  • IL10 initiates potent anti-inflammatory effects via activating its cell surface receptor, composed of IL10RA and IL10RB subunits
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation     loss of function
    loss of function mutations in interleukin-10 (IL10) and interleukin-10 receptors (IL10R) cause severe infantile (very early onset) inflammatory bowel disease (IBD)
    constitutional germinal mutation      
    in patients with early-onset enterocolitis, involving hyperinflammatory immune responses in the intestine
    Susceptibility
  • to schizophrenia
  • rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)
  • Variant & Polymorphism other
  • homozygosity of the IL-10R1 G330R allele is associated with schizophrenia
  • IL10RA G330R may possibly contribute to RA or SLE disease susceptibility
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • inactivation of the Il10 receptor (Il10ra) gene in mice leads to an increased susceptibility to chemically induced colitis as in the classical Il10-deficient mutant