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FLASH GENE
Symbol IGFALS contributors: mct/npt - updated : 26-01-2010
HGNC name insulin-like growth factor binding protein, acid labile subunit
HGNC id 5468
Corresponding disease
ALSD acid-labile subunit deficiency
Location 16p13.3      Physical location : 1.840.415 - 1.844.909
Synonym name acid labile subunit
Synonym symbol(s) ALS
DNA
TYPE functioning gene
STRUCTURE 3.29 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC283951 16p13.3 hypothetical protein LOC283951 LOC388201 16 LOC388201 LOC388202 16 similar to KIAA0445 protein CLCN7 16p13.3 chloride channel 7 LOC390666 16 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 LOC390667 16 similar to Neuronal pentraxin II precursor (NP-II) (NP2) KIAA0683 16p13.3 similar to Neuronal pentraxin II precursor (NP-II) (NP2) KIAA0590 16p13.3 similar to Neuronal pentraxin II precursor (NP-II) (NP2) FLJ20898 16p13.3 hypothetical protein FLJ20898 CRAMP1L 16p13.3 Crm, cramped-like (Drosophila) C16orf34 16p13.3 chromosome 16 open reading frame 34 MAPK8IP3 16p13.3 mitogen-activated protein kinase 8 interacting protein 3 NME3 16q13 non-metastatic cells 3, protein expressed in MRPS34 16p13.3 mitochondrial ribosomal protein S34 LOC390668 16 similar to hypothetical protein 6820428D13 SSB3 16p13.3 SPRY domain-containing SOCS box protein SSB-3 NUBP2 16p13.3 nucleotide binding protein 2 (MinD homolog, E. coli) IGFALS 16p13.3 insulin-like growth factor binding protein, acid labile subunit HAGH 16p13.3 hydroxyacyl glutathione hydrolase DKFZP566J2046 16p13.3 hypothetical protein DKFZp566J2046 MGC35212 16p13.3 hypothetical protein MGC35212 LOC342460 16p13.3 similar to c439A6.1 (novel protein similar to heparan sulfate (glucosamine) 3-O-sulfotransferases) SEPX1 16p13.3 selenoprotein X, 1 RPL3L 16p13.3 ribosomal protein L3-like NDUFB10 16p13.3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa RPS2 16p13.3 ribosomal protein S2 RNF151 16p13.3 ring finger protein 151 TBL3 16p13.3 transducin (beta)-like 3 NOXO1 16p13.3 NADPH oxidase organizer 1 GFER 16p13.3-p13.12 growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae) SYNGR3 16p13 synaptogyrin 3 LOC90850 16p13.3 hypothetical protein LOC90850
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2282 - 643 - Deming (2005)
2 - 2168 - 605 - Deming (2005)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 pancreas exocrine    
Lymphoid/Immunethymus    
Reproductivefemale systemuterus   
 female systembreastmammary gland  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticplasma   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • 27 AA hydrophobic sequence (18 to 20 leucine-rich repeats of 24 AA)
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Igfals
    homolog to murine Igfals
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion
  • having a key role in regulating transendothelial IGF transport, but other factors are also involved (Payet 2004)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • key component of the 150-kD IGF circulating ternary complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ALSD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS