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FLASH GENE
Symbol IGFALS contributors: mct/npt - updated : 26-01-2010
HGNC name insulin-like growth factor binding protein, acid labile subunit
HGNC id 5468
DNA
TYPE functioning gene
STRUCTURE 3.29 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2282 - 643 - Deming (2005)
2 - 2168 - 605 - Deming (2005)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 pancreas exocrine    
Lymphoid/Immunethymus    
Reproductivefemale systemuterus   
 female systembreastmammary gland  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticplasma   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • 27 AA hydrophobic sequence (18 to 20 leucine-rich repeats of 24 AA)
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Igfals
    homolog to murine Igfals
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion
  • having a key role in regulating transendothelial IGF transport, but other factors are also involved (Payet 2004)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • key component of the 150-kD IGF circulating ternary complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ALSD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS