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FLASH GENE
Symbol IGF2BP1 contributors: mct/pgu - updated : 09-07-2010
HGNC name insulin-like growth factor 2 mRNA binding protein 1
HGNC id 28866
Location 17q21.32      Physical location : 47.074.773 - 47.133.505
Synonym name
  • mRNA-binding protein CRDBP
  • coding region determinant-binding protein
  • zipcode binding protein 1
  • IGF II mRNA binding protein 1
  • VICKZ family member 1
  • Synonym symbol(s) IMP1, CRDBP, VICKZ1, ZBP1, IMP-1, CRD-BP
    DNA
    TYPE functioning gene
    STRUCTURE 58.73 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 8352 - 438 - 1999 9891060
  • isoform 2
  • 15 - 8769 - 577 - 1999 9891060
  • isoform 1
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     liver   moderately
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemovary   
     female systemplacenta   
     male systemtestis   
     male systemprostate   
    Respiratorylung    
     respiratory tracttrachea   
    Urinarykidney    
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticprogenitor cell Homo sapiens
    Lymphoid/Immunelymphocyte Homo sapiens
    Muscularmyoblast
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four K homology domains
  • two RNA recognition motifs
  • conjugated PhosphoP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Igf2bp1 (99.3pc)
    homolog to rattus Igf2bp1 (99.7pc)
    Homologene
    FAMILY
  • IGF-II mRNA-binding protein (IMP) family
  • RRM IMP/VICKZ family
  • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    text associated with microtubules and polysomes
    basic FUNCTION
  • regulating IGF2 translation
  • implicated in subcytoplasmic localization of mRNAs during embryogenesis
  • functions by binding to the mRNA of certain genes, including insulin-like growth factor 2, beta actin, and beta-transducin repeat-containing protein and regulating their translation
  • is essential for the induction of both BTRCP1 and c-Myc by beta-catenin signaling in colorectal cancer cells
  • involved in the upregulation of BTRCP1, in the activation of dimeric transcription factor by NF-kappa B and in the suppression of apoptosis in these cancers
  • may act as a regulator of mRNA transport to activated synpases in response to synaptic activity
  • acting as a HIV-1 retrovirus resctriction factor that reduces HIV-1 assembly by inhibiting viral RNA packaging, assembly and processing of HIV-1 GAG protein on cellular membranes
  • oncogenic factor involved in promoting elevated proliferation by stabilizing the c-myc mRNA in ovarian carcinoma cells
  • is likely to play important roles in lung cancer development and progression
  • implicated in RNA regulatory processes such as intracellular RNA localization, RNA stability, and translational control
  • may play a role in cancer cell migration
  • play an important role in colorectal catrcinoma metastasis by shuttling requisite RNAs to the lamellipodia of migrating cells
  • controls spatially restricted BETA-actin (ACTB) mRNA translation and modulates growth cone guidance
  • promotes the velocity and directionality of tumor-derived cell migration by determining the cytoplasmic fate of two novel target mRNAs: MAPK4 and PTEN
  • promotes the velocity and persistence of tumor cell migration by controlling the expression of signaling proteins
  • CELLULAR PROCESS nucleotide, transcription, regulation
    protein, translation regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the coding region determinant (CRD)-mediated complex
  • identified in a HCV IRES-mediated translation complex
  • identified in a mRNP complex
  • in complex with four proteins promotes CRD-mediated c-myc mRNA stabilization
  • INTERACTION
    DNA
    RNA
  • binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA
  • binding to the coding region of BTRCP1 mRNA and stabilizing it, preventing its degradation by attenuating its miRNA-183-dependent interaction with Ago2 ,
  • interacting with both hepatitis C virus 5'UTR and 3'UTR, recruiting EIF3 and enhancing HCV translation
  • small molecule
    protein
  • heterodimerizing with IGF2BP3
  • interacting with HIV-1 GAG
  • interacting with DHX9, ELAVL2, HNRNPA2B1, HNRNPC, HNRNPH1, HNRNPU, IGF2BP2, ILF2, PABPC1, YBX1, FMR1, ELAVL4
  • cell & other
    REGULATION
    inhibited by tumor-suppressive lipooxygenases, resulting in inhibition of prostate carcinoma cell proliferation
    Other upregulated in response to beta-catenin activation
    beta catenin binds to IGF2BP1 promoter and activates its expression in breast cancer cells. Feedback loop regulation, IGF2BP1 associating with beta catenin mRNA and increasing its stability
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    amplified in breast cancer
    tumoral     --over  
    overexpressed in primary malignant melanomas
    tumoral     --over  
    observed preferentially in high-grade and high-stage cases and significant prognostic indicator for reduced recurrence-free and overall survival
    tumoral     --other  
    aberrant expression in diffuse large B-cell
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker prognostic biomarker for lung cancer
    Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    knockdown of IGF2BP1 inhibits NF-KappaB activity, induces apoptosis and suppresses proliferation and tumorigenic properties of melanoma cells
    cancerlung 
    promising therapeutic target for lung cancer
    ANIMAL & CELL MODELS