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FLASH GENE
Symbol IGF2BP1 contributors: mct/pgu - updated : 09-07-2013
HGNC name insulin-like growth factor 2 mRNA binding protein 1
HGNC id 28866
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral        
amplified in breast cancer
tumoral     --over  
overexpressed in primary malignant melanomas
tumoral     --over  
observed preferentially in high-grade and high-stage cases and significant prognostic indicator for reduced recurrence-free and overall survival
tumoral     --other  
aberrant expression in diffuse large B-cell
Susceptibility
Variant & Polymorphism
Candidate gene
Marker prognostic biomarker for lung cancer
Therapy target
SystemTypeDisorderPubmed
cancerskin 
knockdown of IGF2BP1 inhibits NF-KappaB activity, induces apoptosis and suppresses proliferation and tumorigenic properties of melanoma cells
cancerlung 
promising therapeutic target for lung cancer
ANIMAL & CELL MODELS