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FLASH GENE
Symbol IFNG contributors: mct/pgu - updated : 24-10-2014
HGNC name interferon, gamma
HGNC id 5438
Location 12q15      Physical location : 68.548.549 - 68.553.521
Synonym name
  • immune interferon
  • IFN-gamma
  • Synonym symbol(s) IFG, IFI
    DNA
    TYPE virus associated
    STRUCTURE 4.97 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   enhancer
    text structure
  • IFNG and IL26 genes share a common distal enhancer element.
  • MAPPING cloned Y linked N status confirmed
    Physical map
    IRAK3 12q13.13 interleukin-1 receptor-associated kinase 3 RBMS1P 12q14.2 RNA binding motif, single stranded interacting protein 1, pseudogene LOC387866 12 LOC387866 LOC390340 12 similar to IAP-associated factor VIAF1; phosducin-like 2 HELB 12q14.2 helicase (DNA) B GRIP1 12q14.1-q14.2 glutamate receptor interacting protein 1 HGT2 12q14.3 glutamate receptor interacting protein 1 TIP120A 12q14 glutamate receptor interacting protein 1 LOC390341 12 similar to nuclear localization signal containing protein deleted in Velo-Cardio-Facial syndrome DYRK2 12q14.3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 LOC341333 12q14.3 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) IFNG 12q14-q15 interferon, gamma IL26 12q15 interleukin 26 IL22 12q15 interleukin 22 MDM1 12q14.3 nuclear protein double minute 1 LOC160410 12q14.3 proteasome (prosome, macropain) 26S subunit, ATPase, 6 pseudogene LOC387867 12 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) RAP1B 12q14 RAP1B, member of RAS oncogene family LOC246723 12q14 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d pseudogene NUP107 12q14.3 nuclear pore complex protein SLC35E3 12q15 solute carrier family 35, member E2 PRO2268 12q14.3 hypothetical protein PRO2268 MDM2 12q14.3-q15 Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) MGC5370 12q14.3 hypothetical protein MGC5370 CPM 12q15 carboxypeptidase M CPSF6 12q13.2 cleavage and polyadenylation specific factor 6, 68kDa LYZ 12q14-q15 lysozyme (renal amyloidosis) GAS41 12q13-q15 lysozyme (renal amyloidosis) FRS2 12q15 fibroblast growth factor receptor substrate 2 CCT2 12q15 chaperonin containing TCP1, subunit 2 (beta) LOC387868 12 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 VMD2L3 12q14.2-q15 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 MGC13168 12q14.3 hypothetical protein MGC13168 RAB3IP 12q13-q15 RAB3A interacting protein (rabin3) FLJ25056 12q14.3 hypothetical protein FLJ25056
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1986 - 325 - 1995 7587386
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   lowly
    Urinarykidney   lowly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines B cell lines
    fluid/secretion blood at a predominantly level
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • type 2 (or gamma) interferon family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,cytoplasm,organelle,membrane
    text secreted
    basic FUNCTION
  • involved in immunoregulation, negative regulator of T cell mediated osteoclastogenesis through cross talk with TNFSF11
  • involved in the control of endogenous tumor and infection, by upregulating MHC classes I,II, effecting IgG heavy chain switching and stimulating production of immunomodulatory cytokines, surveillance system
  • IFNG binds to an heterotetrameric receptor capable of activating the JAK-STAT pathway, in cooperation with BRCA1, leading to phosphorylation of STAT1 and STAT1 dependent regulation of gene expression, also,STAT1 independent regulator of gene expression
  • inducing rapid degradation of TRAF6, resulting in inhibition of osteoclastogenesis through inhibition of TNFS11 (RANK2) induced activation of NFKB and INK
  • mediating DUOX2 expression in respiratory tract epithelium and thus is involved in the regulation of host defense responses
  • soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and potent activator of macrophages
  • extensively control iron distribution and availability by directly modulating the expression of a number of players in iron metabolism, including ferritin, the transferrin receptor, the iron exporter ferroportin
  • IFNG production is likely essential for hematopoietic stem and progenitor cell (HSPC) activation and hematopoietic responses to infection
  • antiproliferative effects on transformed cells
  • plays an essential role in the development and severity of systemic autoimmunity, particularly systemic lupus erythematosus
  • IFNG dependent signalling controlled trafficking through the choroid plexus, for CNS immune surveillance and repair
  • during the differentiation process NK cells gradually display increasing expression of IFNG and TBX21 (encoding T-bet) transcripts and demethylation at the IFNG promoter
  • CELLULAR PROCESS cell life, proliferation/growth
    cell communication
    PHYSIOLOGICAL PROCESS immunity/defense
    text cell migration motility
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of an heterotetrameric receptor
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SPP1 and IL27 (important IFNG–dependent self-regulatory process that serves to control immune system homeostasis through an SPP1/IL27 axis in dendritic cells)
  • IFNG appears to act largely through a transcriptional mechanism on the FXN gene
  • TWIST1 regulation of IFNG depends on complex formation with RUNX3
  • IFNG- induced soluble and membrane-bound TNFSF13B production in a dose- and time-dependent manner
  • IFNG induces TNFSF13 expression in human intestinal epithelial cells through JAK/STAT signaling pathways that might activate the GAST and IRF1-binding element in the TNFSF13B promoter
  • induces IL33 in keratinocytes and IL33 acts on activated T cells to further increase the release of IFNG, therefore contributing to drive skin inflammation towards chronic responses
  • IRF1 mediates IFNG-induced optineurin promoter activation
  • PRDM1-dependent recruitment of TLE4 to the IFNG locus causes epigenetic silencing of the expression of the IFNG gene in anergic TH1 cells
  • inhibits IFNG -induced biological responses, and IFNG is a new molecular target of NR1H3
  • GBP1 is a downstream processor of IFNG via which T cells regulate cytoskeleton-dependent cell functions 8)
  • directly controls IL33 protein level through a STAT1- and PSMB9-dependent mechanism
  • cell & other
    REGULATION
    Other autoregulating its translation through activation of PRKR
    produced by lmyphocytes activated by specific antigens or mitogens
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • possible susceptibility to rheumatoid arthritis and susceptibility to angiomyolipoma in TSC2
  • to pulmonary tuberculosis
  • Variant & Polymorphism other
  • allele 2 protecting against angiomyolipoma
  • variation in IFNG is associated with the risk of aplastic anemia
  • the haplotype rs2234711T-rs3799488C contributed to a significant increase in the risk of tuberculosis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS