basic FUNCTION
| involved in immunoregulation, negative regulator of T cell mediated osteoclastogenesis through cross talk with TNFSF11 |
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involved in the control of endogenous tumor and infection, by upregulating MHC classes I,II, effecting IgG heavy chain switching and stimulating production of immunomodulatory cytokines, surveillance system |
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IFNG binds to an heterotetrameric receptor capable of activating the JAK-STAT pathway, in cooperation with BRCA1, leading to phosphorylation of STAT1 and STAT1 dependent regulation of gene expression, also,STAT1 independent regulator of gene expression |
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inducing rapid degradation of TRAF6, resulting in inhibition of osteoclastogenesis through inhibition of TNFS11 (RANK2) induced activation of NFKB and INK |
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mediating DUOX2 expression in respiratory tract epithelium and thus is involved in the regulation of host defense responses |
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soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and potent activator of macrophages |
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extensively control iron distribution and availability by directly modulating the expression of a number of players in iron metabolism, including ferritin, the transferrin receptor, the iron exporter ferroportin |
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autocrine IFNG promotes naive CD8 T cell differentiation and synergizes with IFNA1 to stimulate strong function |
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IFNG production is likely essential for hematopoietic stem and progenitor cell (HSPC) activation and hematopoietic responses to infection |
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antiproliferative effects on transformed cells |
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plays an essential role in the development and severity of systemic autoimmunity, particularly systemic lupus erythematosus |
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IFNG dependent signalling controlled trafficking through the choroid plexus, for CNS immune surveillance and repair |
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during the differentiation process NK cells gradually display increasing expression of IFNG and TBX21 (encoding T-bet) transcripts and demethylation at the IFNG promoter |