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FLASH GENE
Symbol IDS contributors: mct - updated : 03-07-2009
HGNC name iduronate 2-sulfatase
HGNC id 5389
Corresponding disease
MPS2 mucopolysaccharidosis, type II
Location Xq28      Physical location : 148.560.294 - 148.586.884
Synonym name
  • idursulfase
  • alpha-L-iduronate sulfate sulfatase
  • iduronate 2-sulfatase 14 kDa chain
    • Synonym symbol(s) SIDS, S
    EC.number 3.1.6.13
    DNA
    TYPE functioning gene
    STRUCTURE 26.57 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    MAPPING cloned Y linked Y status confirmed
    Map cen - DXS369 - DXS8028 - DXS1200 - DXS181 - DXS297 - DXS998 - DXS532 - DXS548 - FRAXA - DXS308 - DXS465 - DXS293 - DXS533 - DXS1215 - DXS8091 - FRAXE /DXS296 - (DXS295 - DXS185 ),(DXS1193 - DXS1123 - IDS - DXS1113 ) - IDSP1 - DXS466 - DXS29 - DXS49 - DXS304 - DXS305 - DXS52 - qter
    Text see FRAXA , FRAXE , IDSCR
    Physical map
    FMR1 Xq27.3 fragile X mental retardation 1 FLJ25736 LOC286397 Xq28 similar to Ferritin heavy chain (Ferritin H subunit) LOC389899 X similar to HS1 binding protein LOC347509 Xq28 similar to ribosomal protein L7-like 1 FMR2 Xq28 fragile X mental retardation 2 IDS Xq27.3-q28 iduronate 2-sulfatase (Hunter syndrome) IDSP1 Xq28 iduronate 2-sulfatase pseudogene 1 LOC91966 Xq28 hypothetical protein LOC91966 LOC347512 Xq28 similar to Heat shock transcription factor, Y-linked (Heat shock transcription factor 2-like protein) (HSF2-like) LW-1 Xq28 similar to Heat shock transcription factor, Y-linked (Heat shock transcription factor 2-like protein) (HSF2-like) FAM11A Xq28 similar to Heat shock transcription factor, Y-linked (Heat shock transcription factor 2-like protein) (HSF2-like) LOC392556 X similar to Melanoma-associated antigen 11 (MAGE-11 antigen) MAGEA11 Xq28 melanoma antigen, family A, 11 MAGEA9 Xq28 melanoma antigen, family A, 9 MAGEA7 Xq28 melanoma antigen, family A, 7, pseudogene MAGEA8 Xq28 melanoma antigen, family A, 8 LOC389900 X similar to DKFZP586L0724 protein LOC389901 X similar to ATP-dependent DNA helicase II, 70 kDa subunit (Lupus Ku autoantigen protein p70) (Ku70) (70 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) (CTC box binding factor 75 kDa subunit) (CTCBF) (CTC75) CXorf6 Xq28 chromosome X open reading frame 6 MTM1 Xq28 myotubular myopathy 1 MTMR1 Xq28 myotubularin related protein 1 CD99L2 Xq28 CD99 antigen-like 2 HMGB3 Xq28 high-mobility group box 3 LOC392557 X similar to hypothetical protein GPR50 Xq28 G protein-coupled receptor 50 LOC286456 Xq28 similar to NGFI-A binding protein 1; NGFI-A-binding protein 1; EGR1 binding protein 1 LOC139135 Xq28 hypothetical protein LOC139135 TMG3 Xq28 transmembrane gamma-carboxyglutamic acid protein 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 5876 61.8 550 - 2007 17655837
    8 - 1437 - 343 - 2007 17655837
    - - 5832 - 460 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Connectivebone   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    Blood/Hematopoieticleukocyte
    Digestivehepatocyte
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • sulfatase domain
    • HOMOLOGY
    interspecies homolog to murine Ids
    Homologene
    FAMILY
  • sulfatase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • iduronate 2-sulfatase, acting on dermatan sulfate, heparan sulfate
  • catalyzing the first step of degradation of glucosaminoglycans (mucopolysaccharides)
  • lysosomal exo-sulphatase involved in the degradation of the glycosaminoglycans heparan sulphate and dermatan sulphate
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other targeted to the lysosome by M6P receptor mediated pathway
    ASSOCIATED DISORDERS
    corresponding disease(s) MPS2
    related resource Mucopolysaccharidosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS