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FLASH GENE
Symbol IDS contributors: mct - updated : 03-07-2009
HGNC name iduronate 2-sulfatase
HGNC id 5389
Corresponding disease
MPS2 mucopolysaccharidosis, type II
Location Xq28      Physical location : 148.560.294 - 148.586.884
Synonym name
  • idursulfase
  • alpha-L-iduronate sulfate sulfatase
  • iduronate 2-sulfatase 14 kDa chain
    • Synonym symbol(s) SIDS, S
    EC.number 3.1.6.13
    DNA
    TYPE functioning gene
    STRUCTURE 26.57 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    MAPPING cloned Y linked Y status confirmed
    Map cen - DXS369 - DXS8028 - DXS1200 - DXS181 - DXS297 - DXS998 - DXS532 - DXS548 - FRAXA - DXS308 - DXS465 - DXS293 - DXS533 - DXS1215 - DXS8091 - FRAXE /DXS296 - (DXS295 - DXS185 ),(DXS1193 - DXS1123 - IDS - DXS1113 ) - IDSP1 - DXS466 - DXS29 - DXS49 - DXS304 - DXS305 - DXS52 - qter
    Text see FRAXA , FRAXE , IDSCR
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 5876 61.8 550 - 2007 17655837
    8 - 1437 - 343 - 2007 17655837
    - - 5832 - 460 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Connectivebone   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    Blood/Hematopoieticleukocyte
    Digestivehepatocyte
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • sulfatase domain
    • HOMOLOGY
    interspecies homolog to murine Ids
    Homologene
    FAMILY
  • sulfatase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • iduronate 2-sulfatase, acting on dermatan sulfate, heparan sulfate
  • catalyzing the first step of degradation of glucosaminoglycans (mucopolysaccharides)
  • lysosomal exo-sulphatase involved in the degradation of the glycosaminoglycans heparan sulphate and dermatan sulphate
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other targeted to the lysosome by M6P receptor mediated pathway
    ASSOCIATED DISORDERS
    corresponding disease(s) MPS2
    related resource Mucopolysaccharidosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS