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FLASH GENE
Symbol ICAM4 contributors: npt/ - updated : 14-03-2007
HGNC name intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
HGNC id 5347
Corresponding disease
LW Landsteiner-Wiener blood group
Location 19p13.2-cen      Physical location : 10.397.649 - 10.399.198
Synonym name
  • Landsteiner-Wiener blood group
  • intercellular adhesion molecule 4 (LW blood group)
  • CD242 antigen
  • LW blood group protein
    • Synonym symbol(s) LW, CD242, ICAM-4
    DNA
    TYPE functioning gene
    STRUCTURE 1.55 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1420 23.7 237 - -
    - - 1273 27 271 - -
    - - 1196 27.4 272 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerthrocyte
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal sequence an extracellular region
  • two Ig-like domains
  • a single transmembrane segment
  • a cytoplasmic C terminus
    • HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • ICAM family
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • adhesion molecule that binds to leukocyte adhesion LFA1 protein (integrin alpha-l/beta-2)
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LW
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS