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FLASH GENE
Symbol HYDIN contributors: mct - updated : 13-10-2012
HGNC name hydrocephalus inducing
HGNC id 19368
Corresponding disease
ICS19 immotile cilia syndrome 19
Location 16q22.2      Physical location : 70.841.289 - 71.264.569
Synonym name
  • protein phosphatase 1, regulatory subunit 31
  • Synonym symbol(s) FLJ12871, FLJ14665, KIAA1864, HYDIN1, HYDIN2, PPP1R31
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text duplicated onto chromosome 1 (HYDIN2)
    STRUCTURE 423.34 kb     86 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    MAPPING cloned Y linked N status provisional
    Physical map
    SNTB2 16q22-q23 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) VPS4A 16q23.1 vacuolar protein sorting 4A (yeast) COG8 16q22.1 component of oligomeric golgi complex 8 PDF 16q22.1 peptide deformylase-like protein CGI-37 16q22.1 comparative gene identification transcript 37 MGC23911 16q22.1 hypothetical protein MGC23911 TERF2 16q22.1 telomeric repeat binding factor 2 CYB5-M 16q22.1 cytochrome b5 outer mitochondrial membrane precursor NFAT5 16q22.1 nuclear factor of activated T-cells 5, tonicity-responsive NQO1 16q12-q22 NAD(P)H dehydrogenase, quinone 1 NOB1P 16q22.3 likely ortholog of mouse nin one binding protein LOC388285 16 hypothetical gene supported by U89867; NM_007363 WWP2 16q22.1 Nedd-4-like ubiquitin-protein ligase LOC348174 16q22.1 secretory protein LOC348174 LOC390737 16 similar to MGC9515 protein LOC283970 16q22.1 hypothetical protein LOC283970 PDPR 16q22.1 pyruvate dehydrogenase phosphatase regulatory subunit MGC34761 16q22.1 hypothetical protein MGC34761 LOC388286 16 hypothetical gene supported by AF395444; NM_014006 MTR3 16q22.1 homolog of yeast mRNA transport regulator 3 AARS 16q22.1 alanyl-tRNA synthetase DDX19 16q22.1 DEAD (Asp-Glu-Ala-As) box polypeptide 19 FLJ11126 16q22.1 hypothetical protein FLJ11126 SIAT4B 16q22.3 sialyltransferase 4B (beta-galactoside alpha-2,3-sialyltransferase) FUK 16q22.1 fucokinase COG4 16q22.3 component of oligomeric golgi complex 4 SF3B3 16q22.1 splicing factor 3b, subunit 3, 130kDa MGC34647 16q22.1 hypothetical protein MGC34647 LOC92154 16q22.1 hypothetical protein BC002770 FLJ10305 16q22.1 hypothetical protein FLJ10305 HYDIN 16q22.2 hydrocephalus inducing LOC388287 16 similar to hydrocephalus-inducing protein FLJ14665 16q22.2 hypothetical protein FLJ14665 DKFZp434L0850 16q22.2 hypothetical protein DKFZp434L0850 FLJ11171 16q22.2 hypothetical protein FLJ11171 LOC388288 16 similar to hypothetical protein (L1H 3 region) - human CALB2 16q22.2 calbindin 2, 29kDa (calretinin) ZNF23 16q22.2 zinc finger protein 23 (KOX 16) LOC390738 16 similar to mKIAA1261 protein ZNF19 16q23.1 zinc finger protein 19 (KOX 12) CHST4 16q23.1 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 TAT 16q22.1 tyrosine aminotransferase LOC91862 16q22.2 similar to RIKEN cDNA 1810006A16 gene KIAA0931 16q23.1 similar to RIKEN cDNA 1810006A16 gene AP1G1 16q23 adaptor-related protein complex 1, gamma 1 subunit LOC342371 16q22.2 similar to Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog) LOC55565 16q22.2 hypothetical protein LOC55565 KIAA0174 16q23.1 hypothetical protein LOC55565 PKD1L3 16q22.2 polycystic kidney disease 1-like 3 DHODH 16q22 dihydroorotate dehydrogenase HP 16q22.2 haptoglobin HPR 16q22.2 haptoglobin-related protein FLJ20511 16q22.2 hypothetical protein FLJ20511 DHX38 16q21-q22.3 DEAH (Asp-Glu-Ala-His) box polypeptide 38 PMFBP1 16q23.1 polyamine modulated factor 1 binding protein 1 LOC390739 16 similar to C-Myc binding protein (Associate of Myc 1) (AMY-1)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    86 - 15746 575.8 5120 - 2006 16938426
    20 - 3718 114.2 1017 - 2006 16938426
    19 - 3152 106.3 950 - 2006 16938426
    19 - 3122 105.3 940 - 2006 16938426
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Reproductivemale systemtestis  highly
    Visualeyeretina  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • potential central pair protein required for ciliary motility
  • axonemal protein, involved in growth and microtubule motility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ICS19
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice with Hydin defects develop lethal hydrocephalus, and hydrocephalus is caused by a central pair defect impairing ciliary motility and fluid transport in the brain