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FLASH GENE
Symbol HYAL2 contributors: - updated : 07-04-2007
HGNC name hyaluronoglucosaminidase 2
HGNC id 5321
Location 3p21.3      Physical location : 50.355.220 - 50.360.281
Synonym name
  • PH-20 homolog
  • hyaluronidase 2
  • lysosomal hyaluronidase
  • Synonym symbol(s) LUCA2
    EC.number 3.2.1.35
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered with HYAL1 and HYAL3
    STRUCTURE 4.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    SEMA3F 3p21.31 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F GNAT1 3p21.2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 SLC38A3 3p21.3 solute carrier family 38, member 3 GNAI2 3p21.31 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 SEMA3B 3p21.3 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B FLJ38608 3p21.31 hypothetical protein FLJ38608 IFRD2 3p21.3 interferon-related developmental regulator 2 HYAL3 3p21.3 hyaluronoglucosaminidase 3 FUS2 3p21.3 putative tumor suppressor HYAL1 3p21.3 hyaluronoglucosaminidase 1 HYAL2 3p21.3 hyaluronoglucosaminidase 2 PDAP2 3p21.3 PDGFA associated protein 2 RASSF1 3p21.3 Ras association (RalGDS/AF-6) domain family 1 ZMYND10 3p21.3 zinc finger, MYND domain containing 10 NPR2L 101F6 3p21.3 putative tumor suppressor 101F6 PL6 3p21.3 placental protein 6 CACNA2D2 3p21.3 calcium channel, voltage-dependent, alpha 2/delta subunit 2
    RNA
    TRANSCRIPTS type messenger
    text the same protein is produced by both variants
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1848 54 473 - Lepperdinger, 98
    - splicing 1909 54 473 - Lepperdinger, 98
    encodes the same protein as variant 1
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
     nervecranial nerve  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide in the N-terminus
  • an EGF-like domain
  • isoforms Precursor a preprotein with 473 aminoacids
    HOMOLOGY
    interspecies homolog to murine Hyal2
    intraspecies homolog to testicular SPAM1
    Homologene
    FAMILY glycosyl hydrolase 56 family
    CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lysosome
    text
  • Vacuole
  • Glycosylphosphatidylinositol (GPI)-anchored cell surface protein
  • basic FUNCTION
  • involved in glycosaminoglycan catabolism
  • lysosomal hyaluronidase which specifically hydrolyzes high molecular weight hyaluronan
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with MST1R (negatively regulates MST1R and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in lung tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS