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FLASH GENE
Symbol HYAL2 contributors: - updated : 07-04-2007
HGNC name hyaluronoglucosaminidase 2
HGNC id 5321
Location 3p21.3      Physical location : 50.355.220 - 50.360.281
Synonym name
  • PH-20 homolog
  • hyaluronidase 2
  • lysosomal hyaluronidase
    • Synonym symbol(s) LUCA2
    EC.number 3.2.1.35
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered with HYAL1 and HYAL3
    STRUCTURE 4.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    text the same protein is produced by both variants
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1848 54 473 - Lepperdinger, 98
    - splicing 1909 54 473 - Lepperdinger, 98
    encodes the same protein as variant 1
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
     nervecranial nerve  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide in the N-terminus
  • an EGF-like domain
    • isoforms Precursor a preprotein with 473 aminoacids
    HOMOLOGY
    interspecies homolog to murine Hyal2
    intraspecies homolog to testicular SPAM1
    Homologene
    FAMILY glycosyl hydrolase 56 family
    CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lysosome
    text
  • Vacuole
  • Glycosylphosphatidylinositol (GPI)-anchored cell surface protein
    • basic FUNCTION
  • involved in glycosaminoglycan catabolism
  • lysosomal hyaluronidase which specifically hydrolyzes high molecular weight hyaluronan
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with MST1R (negatively regulates MST1R and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in lung tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS