Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

HYAL2

contributors: - updated : 07-04-2007

HGNC name	hyaluronoglucosaminidase 2
HGNC id	5321

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	the same protein is produced by both variants

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 1848 54 473 - Lepperdinger, 98 variant 2 - splicing 1909 54 473 - Lepperdinger, 98 encodes the same protein as variant 1

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly Nervous brain           nerve cranial nerve     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide in the N-terminus
	an EGF-like domain

isoforms

Precursor

a preprotein with 473 aminoacids

HOMOLOGY

interspecies

homolog to murine Hyal2

intraspecies

homolog to testicular SPAM1

Homologene

FAMILY

glycosyl hydrolase 56 family

CATEGORY

enzyme , tumor suppressor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,lysosome
text	Vacuole
	Glycosylphosphatidylinositol (GPI)-anchored cell surface protein

basic FUNCTION	involved in glycosaminoglycan catabolism
	lysosomal hyaluronidase which specifically hydrolyzes high molecular weight hyaluronan

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacts with MST1R (negatively regulates MST1R and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in lung tumor

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS