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FLASH GENE

Symbol

HTR3B

contributors: mct - updated : 02-04-2007

HGNC name	5-hydroxytryptamine (serotonin) receptor 3B
HGNC id	5298

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q23.1      Physical location : 113.775.588 - 113.817.282
Synonym symbol(s)	5-HT3B

DNA

TYPE	functioning gene
STRUCTURE	41.00 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	alternative promoter
text structure	tissue specific alternative promoters in human brain and intestine

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 1847 variant 1 50 441 small intestine, colon Tzvetkov first variant described variant 2 - - - variant 2 - - central nervous system Tzvetkov lacking exon 1 upstream extended exon 2 potential start codon in extended exon 2

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         intestine large intestine colon     Lymphoid/Immune lymph node         Nervous brain diencephalon amygdala       brain basal nuclei caudate nucleus       brain diencephalon hypothalamus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central

cells

System Cell Pubmed Species Stage Rna symbol Visual cone photoreceptor Visual rod photoreceptor

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four transmembrane segments (4TM)

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	homolog to chimpanzee HTR3B (98.85 pc)
	homolog to rattus Htr3b (73.21 pc)
	homolog to murine Htr3b (73.90 pc)

Homologene

FAMILY

CATEGORY

receptor membrane ligand ion channel , transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
text	coexpressed with HTR3A

basic FUNCTION	biogenic hormone functioning as a neurotransmitter, a hormone, and a mitogen
	causes fast, depolarizing responses in neurons after activation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

neurotransmission

neuronal transmission

a component

component of HTR3 receptor heterodimerizing with HTR3A to form a fully functional receptor with a large single channel conductance, mediating rapid excitatory responses

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to bipolar affective disorder to major depression

Variant & Polymorphism SNP , other	SNP influencing development of bipolar affectve disorder
	Y129S exists in high frequency in the general population and has been shown to be inversely correlated to the incidence of major depression in women

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS