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FLASH GENE
Symbol HTR3B contributors: mct - updated : 02-04-2007
HGNC name 5-hydroxytryptamine (serotonin) receptor 3B
HGNC id 5298
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
four transmembrane segments (4TM)
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to chimpanzee HTR3B (98.85 pc)
homolog to rattus Htr3b (73.21 pc)
homolog to murine Htr3b (73.90 pc)
Homologene
FAMILY
CATEGORY receptor membrane ligand ion channel , transport channel
SUBCELLULAR LOCALIZATION     plasma membrane
text coexpressed with HTR3A
basic FUNCTION
  • biogenic hormone functioning as a neurotransmitter, a hormone, and a mitogen
  • causes fast, depolarizing responses in neurons after activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    neuronal transmission
    a component component of HTR3 receptor heterodimerizing with HTR3A to form a fully functional receptor with a large single channel conductance, mediating rapid excitatory responses
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to bipolar affective disorder
  • to major depression
  • Variant & Polymorphism SNP , other
  • SNP influencing development of bipolar affectve disorder
  • Y129S exists in high frequency in the general population and has been shown to be inversely correlated to the incidence of major depression in women
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS