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FLASH GENE
Symbol HTR1A contributors: mct - updated : 26-08-2008
HGNC name 5-hydroxytryptamine (serotonin) receptor 1A
HGNC id 5286
Location 5q11.2-q13      Physical location : 63.256.278 - 63.257.546
Synonym symbol(s) 5-HT1A, ADRBRL1, ADRB2RL1
DNA
TYPE functioning gene
STRUCTURE 1.00 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Physical map
XTP1 5q12.1 HBxAg transactivated protein 1 LOC391790 5 similar to KRT8 protein FLJ23563 5q12.1 hypothetical protein FLJ23563 CKN1 5q11.1-q11.2 Cockayne syndrome 1 (classical) FLJ12595 5q12.1 hypothetical protein FLJ12595 LOC91942 5q12.1 hypothetical protein LOC91942 LOC389292 5 LOC389292 LOC57399 5q12.1 uncharacterized gastric protein ZA52P ZSWIM6 5q12.1 zinc finger, SWIM domain containing 6 FLJ37543 5q12.1-q12.2 hypothetical protein FLJ37543 KIF2 5q12-q13 kinesin heavy chain member 2 HSA9761 5q11-q14 putative dimethyladenosine transferase IPO11 5q12.1 importin 11 LOC246715 5q12.2 cell division control protein CKS1 pseudogene SLRN 5q12.1 synleurin LOC389293 5 similar to hypothetical protein HTR1A 5q11.2-q13 5-hydroxytryptamine (serotonin) receptor 1A LOC285671 5q12.3 hypothetical protein LOC285671 MRPL49P1 5q12.1 hypothetical protein LOC285671 LOC133993 5q12.3 similar to hypothetical protein MGC52498 FLJ36754 5q12.3 hypothetical protein FLJ36754 SDCCAG10 5q12.3 serologically defined colon cancer antigen 10 LOC345667 5q12.3 similar to ADAMTS-10 precursor (A disintegrin and metalloproteinase with thrombospondin motifs 10) (ADAM-TS 10) (ADAM-TS10) ADAMTS6 5pter-qter a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6 FKSG14 5p15.2-q12.3 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6 KIAA0073 5q12.3 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6 ARFD1 5q12.3 ADP-ribosylation factor domain protein 1, 64kDa FLJ13611 5q12.3 hypothetical protein FLJ13611 SGTB 5q12.3 small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta NLN 5q13.1 neurolysin (metallopeptidase M3 family) ERBB2IP 5q12.2 erbb2 interacting protein SFRS12 5q12.3 splicing factor, arginine/serine-rich 12 LOC202227 5q13.1 similar to peptidylprolyl isomerase A (cyclophilin A) LOC375449 5q13.1 similar to microtubule associated testis specific serine/threonine protein kinase KIAA0303 5q11.2-q12 similar to microtubule associated testis specific serine/threonine protein kinase LY64 5q12 lymphocyte antigen 64 homolog, radioprotective 105kDa (mouse)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1269 - 422 - Kato (2008)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainlimbic systemhippocampus  
cells
SystemCellPubmedSpeciesStageRna symbol
Nervouspyramidal cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
conjugated GlycoP
HOMOLOGY
interspecies ortholog to rattus Htr1a
ortholog to murine Htr1a
ortholog to dog Htr1a
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
text
  • integral to plasma membrane
  • basic FUNCTION
  • inhibiting adenylate cyclase
  • functions as a neurotransmitter, a hormone, and a mitogen
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS