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FLASH GENE
Symbol HSPB1 contributors: mct/pgu - updated : 11-01-2010
HGNC name heat shock 27kDa protein 1
HGNC id 5246
Corresponding disease
CMT2F Charcot-Marie-Tooth disease, axonal, type 2F
Location 7q11.23      Physical location : 75.931.874 - 75.933.613
Synonym name
  • heat shock protein beta-1
  • stress-responsive protein 27
  • estrogen-regulated 24 kDa protein
  • 28 kDa heat shock protein
  • Synonym symbol(s) HSP27, HSP25, HSP28, HMN2B, SRP27, DKFZp586P1322, HS.76067
    DNA
    TYPE functioning gene
    STRUCTURE 1.74 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC392058 7 similar to opposite strand transcription unit to Stag3; Gats protein PMS2L2 7q11-q22 postmeiotic segregation increased 2-like 2 LOC222190 7q11.23 hypothetical gene supported by AK024602 DKFZP434A0131 7q11.23-q21.1 DKFZp434A0131 protein TRIM50B 7q11.23 tripartite motif-containing 50B WBSCR20B 7q11.23 tripartite motif-containing 50B LOC340318 7q11.23 hypothetical protein LOC340318 PMS2L9 7q11.23 postmeiotic segregation increased 2-like 9 HIP1 7q11.23 huntingtin interacting protein 1 CCL26 7q11.23 chemokine (C-C motif) ligand 26 CCL24 7q11.23 chemokine (C-C motif) ligand 24 LOC392059 7 similar to ALY NPD007 7q11.23 NPD007 protein POR 7q11.2 P450 (cytochrome) oxidoreductase TMPIT 7q11.23 transmembrane protein induced by tumor necrosis factor alpha MK-STYX 7q11.23 map kinase phosphatase-like protein MK-STYX MDH2 7cen-q22 malate dehydrogenase 2, NAD (mitochondrial) LOC389525 7 similar to hypothetical protein LOC285908 LOC392060 7 similar to GrpE protein homolog 1, mitochondrial precursor (Mt-GrpE#1) (HMGE) LOC392061 7 similar to GTF2I repeat domain containing 1 isoform 2; Williams-Beuren syndrome chromosome region 11; GTF2I repeat domain-containing 1; general transcription factor 3; muscle TFII-I repeat domain-containing protein 1 alpha 1 FLJ37078 7q11.23 hypothetical protein FLJ37078 HSPB1 7q11.23 heat shock 27kDa protein 1 YWHAG 7q11.23 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide LOC392062 7 similar to peptidylprolyl isomerase A SRCRB4D 7p12.3 scavenger receptor cysteine rich domain containing, group B (4 domains) ZP3 7q11.23 zona pellucida glycoprotein 3 (sperm receptor) DTX2 7p12.3 deltex homolog 2 (Drosophila) UPK3B 7q11.2 uroplakin 3B POMZP3 7q11.23 POM (POM121 homolog, rat) and ZP3 fusion LOC392063 7 similar to Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) LOC370523 7q11.23 similar to deltex 2 LOC389526 7 hypothetical gene supported by AK024602 LOC389527 7 similar to PMS4 homolog mismatch repair protein - human LOC202802 7q11.23 similar to Williams Beuren syndrome chromosome region 19 FGL2 7q11.2 fibrinogen-like 2 LOC54103 7q21.11 hypothetical protein LOC54103 LOC392064 7 similar to hypothetical protein LOC392065 7 similar to beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase; Glucosaminyl (N-acetyl) transferase 1, core 2; beta-1,6-N-acetylglucosaminyltransferase PTPN12 7q11.23 protein tyrosine phosphatase, non-receptor type 12 LOC389528 7 hypothetical gene supported by AF290475; BC037783
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 914 22.7 205 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon highly
    Endocrinepancreas   highly
    Reproductivefemale systemovary  highly
    Urinarybladder   highly
    Visualeyeanterior segmentcornea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminus involved in multimerization
  • C terminus with the alpha cristallin domain responsible for chaperone function
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Hspb1 (84.9pc)
    homolog to rattus Hspb1 (83.4pc)
    intraspecies homolog to estrogen receptor
    Homologene
    FAMILY
  • small heat shock protein (HSP20) family
  • Hsp20/alpha crystallin subfamily
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • translocates from the cytoplasm to the nucleus upon stress induction or heat shock
  • cytoplasmic in interphase cells
  • colocalized with mitotic spindle in mitotic cells
  • basic FUNCTION
  • heat induced inhibitor of eIF4F dependent mRNA translation
  • overexpression associated with regulation of gene expression in keratinocytes
  • protects hippocampal progenitor cells from glucocorticoid-induced apoptotic cell death
  • involved in stress resitance and actin organization
  • atheroprotective, possibly by competing for uptake of atherogenic lipids by macrophages or by attenuating inflammation
  • can modulate SP1-dependent transcriptional activity to promote neuronal protection
  • involved in stress resistance and actin organization
  • may acts as a SUMO-E3 ligase specific for SUMO-E2/3
  • mediator of repression of AR function by PRKD1
  • facilitates the palmitoylation and plasma membrane translocation of the three classes of sex steroid receptors
  • CELLULAR PROCESS cell life, antiapoptosis
    nucleotide, transcription, regulation
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    text inhibition
    PATHWAY
    metabolism
    signaling
    a component
  • cap initiation complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding eIF4G end facilitating dissociation of cap initiation complexes
  • interacting with the transcription factor SP1
  • interacting with the TGFB1I1
  • associating with alpha and beta-tubulin, microtubules and CRYAB
  • interacting with HSPB8 and HSPBAP1
  • MAPKAPK5 is involved in HSPB1-controlled F-actin dynamics in response to activation of the cAMP-dependent protein kinase pathway
  • binding to the SUMO-E2-conjugating enzyme
  • binds to a motif in estrogen receptor alpha (ESR1) and promotes palmitoylation of the steroid receptors
  • facilitates the trafficking of endogenous ESR1 to the plasma membrane
  • unphosphorylated HSPB1 has an inhibitory effect on BGLAP synthesis, but has a stimulatory effect on mineralization, in osteoblasts
  • interaction between SMURF2 and HSPB1, which suggested that SMURF2 mediated ubiquitylation-dependent degradation of HSPB1
  • cell & other
    REGULATION
    induced by environmental stress and developmental changes
    Phosphorylated by MAP3K12 (MAP3K12 is sufficient by itself to induce HSPB1 phosphorylation, cell periphery localization, and redistribution to the insoluble protein fraction (cytoskeleton) in poorly differentiated keratinocytes) (
    Other up-regulated in response to enterovirus 71 infection
    phosphorylated in MCF-7 cells on exposure to protein kinase C activators and heat shock
    ASSOCIATED DISORDERS
    corresponding disease(s) CMT2F
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    constitutional     --low  
    in atherosclerotic plaques
    constitutional     --over  
    in acute coronary syndrome
    tumoral     --over  
    is increased in chroni pancreatitis and pancreatic carcinoma
    Susceptibility
  • lower lymphocyte HSPB1 levels might be associated with an increased risk of lung cancer
  • Variant & Polymorphism
    Candidate gene
  • defects in these gene are cause of distal hereditary motor neuropathy
  • expression of HSPB1 is an accurate and independent predictive biomarker of aggressive disease with a poor clinical outcome in prostate cancer without ETS-gene rearrangement
  • potentail novel serum marker for the diagnosis of chronic obstructive pulmonary disease in the smoking population
  • altered expression of this protein in testes showing abnormal spermatogenesis may be related to the pathogenesis of male infertility
  • Marker
    Therapy target
  • PEP1-HSPB1 fusion protein may be a potential therapeutic agent for familial amyotrophic lateral sclerosis patients
  • may be a clinical target in patients with 5-FU-resistant colon cancer
  • target for interrupting signaling from membrane sex steroid receptors to tumor biology in hormone-responsive cancers
  • ANIMAL & CELL MODELS