| 1 | EXOC3, HSPB1, HSPB2, MAPK14
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| Sec6 enhances cell migration and suppresses apoptosis by elevating the phosphorylation of p38 MAPK, MK2, and HSP27.
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| Tanaka T, Iino M, Goto K.
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| Cell Signal 49:1-16. doi: 10.1016/j.cellsig.2018.04.009. Epub 2018 May 2.
2018
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| 2 | HSPB1
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| The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer.
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| Okuno M, Adachi S, Kozawa O, Shimizu M, Yasuda I.
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| Int J Mol Sci 17(1). pii: E137. doi: 10.3390/ijms17010137. Review.
2016
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| 3 | EIF4E, HSPB1
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| Unphosphorylated HSP27 (HSPB1) regulates the translation initiation process via a direct association with eIF4E in osteoblasts.
|
| Kuroyanagi G, Tokuda H, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O, Otsuka T.
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| Int J Mol Med 36(3):881-9. doi: 10.3892/ijmm.2015.2274. Epub 2015 Jul 7.
2015
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| 4 | CMT2F, HSPB1
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| Characterization of Mutants of Human Small Heat Shock Protein HspB1 Carrying Replacements in the N-Terminal Domain and Associated with Hereditary Motor Neuron Diseases.
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| Muranova LK, Weeks SD, Strelkov SV, Gusev NB.
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| PLoS One 10(5):e0126248. doi: 10.1371/journal.pone.0126248. eCollection 2015.
2015
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| 5 | HMGB1, HSPB1
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| High-mobility group box 1-mediated heat shock protein beta 1 expression attenuates mitochondrial dysfunction and apoptosis.
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| Narumi T, Shishido T, Otaki Y, Kadowaki S, Honda Y, Funayama A, Honda S, Hasegawa H, Kinoshita D, Yokoyama M, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Watanabe T, Tanaka A, Woo CH, Abe J, Takeishi Y, Kubota I.
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| J Mol Cell Cardiol 82:1-12. doi: 10.1016/j.yjmcc.2015.02.018. Epub 2015 Feb 28.
2015
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| 6 | HSPB1
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| HSPB1 as a novel regulator of ferroptotic cancer cell death.
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| Sun X, Ou Z, Xie M, Kang R, Fan Y, Niu X, Wang H, Cao L, Tang D.
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| Oncogene 34(45):5617-25. doi: 10.1038/onc.2015.32. Epub 2015 Mar 2.
2015
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| 7 | CMT2F, HSPB1
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| Charcot-Marie-Tooth 2F: phenotypic presentation of the Arg136Leu HSP27 mutation in a multigenerational family.
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| Stancanelli C, Fabrizi GM, Ferrarini M, Cavallaro T, Taioli F, Di Leo R, Russo M, Gentile L, Toscano A, Vita G, Mazzeo A.
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| Neurol Sci 36(6):1003-6. doi: 10.1007/s10072-014-2050-8. Epub 2014 Dec 30.
2015
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| 8 | HSPB1
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| Hsp27 (HSPB1) differential expression in normal salivary glands and pleomorphic adenomas and association with an increased Bcl2/Bax ratio.
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| Siqueira EC, Souza FT, Diniz MG, Gomez RS, Gomes CC.
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| Tumour Biol 36(1):213-7. doi: 10.1007/s13277-014-2634-1. Epub 2014 Sep 18.
2015
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| 9 | HSPB1, HSPB2, NOX4, TGFB1I1
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| Hic-5 Mediates TGFβ-Induced Adhesion in Vascular Smooth Muscle Cells by a Nox4-Dependent Mechanism.
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| Fernandez I, Martin-Garrido A, Zhou DW, Clempus RE, Seidel-Rogol B, Valdivia A, Lassègue B, García AJ, Griendling KK, San Martin A.
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| Arterioscler Thromb Vasc Biol 35(5):1198-206. doi: 10.1161/ATVBAHA.114.305185. Epub 2015 Mar 26.
2015
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| 10 | HSPB1, NLK
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| Association of nuclear-localized Nemo-like kinase with heat-shock protein 27 inhibits apoptosis in human breast cancer cells.
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| Shaw-Hallgren G, Chmielarska Masoumi K, Zarrizi R, Hellman U, Karlsson P, Helou K, Massoumi R.
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| PLoS One 9(5):e96506. doi: 10.1371/journal.pone.0096506. eCollection 2014.
2014
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| 11 | HSPB1
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| Phosphorylation of heat shock protein 27 antagonizes TNF-α induced HeLa cell apoptosis via regulating TAK1 ubiquitination and activation of p38 and ERK signaling.
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| Qi Z, Shen L, Zhou H, Jiang Y, Lan L, Luo L, Yin Z.
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| Cell Signal 26(7):1616-25. doi: 10.1016/j.cellsig.2014.03.015. Epub 2014 Mar 29.
2014
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| 12 | HSPB1
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| Silencing heat shock protein 27 (HSP27) inhibits the proliferation and migration of vascular smooth muscle cells in vitro.
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| Huang J, Xie LD, Luo L, Zheng SL, Wang HJ, Xu CS.
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| Mol Cell Biochem 390(1-2):115-21. doi: 10.1007/s11010-014-1962-1. Epub 2014 Jan 28.
2014
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| 13 | HSPB1
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| Heat shock protein 27 phosphorylation is involved in epithelial cell apoptosis as well as epithelial migration during corneal epithelial wound healing.
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| Song IS, Kang SS, Kim ES, Park HM, Choi CY, Tchah H, Kim JY.
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| Exp Eye Res 118:36-41. doi: 10.1016/j.exer.2013.11.002. Epub 2013 Nov 15.
2014
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| 14 | HSPB1
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| Heat shock protein B1-deficient mice display impaired wound healing.
|
| Crowe J, Aubareda A, McNamee K, Przybycien PM, Lu X, Williams RO, Bou-Gharios G, Saklatvala J, Dean JL.
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| PLoS One 8(10):e77383. doi: 10.1371/journal.pone.0077383. eCollection 2013.
2013
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| 15 | HSPB1
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| HSPB1 facilitates the formation of non-centrosomal microtubules.
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| Almeida-Souza L, Asselbergh B, De Winter V, Goethals S, Timmerman V, Janssens S.
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| PLoS One 8(6):e66541. doi: 10.1371/journal.pone.0066541. Print 2013.
2013
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| 16 | HSPB1
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| Hsp27 regulates epithelial mesenchymal transition, metastasis, and circulating tumor cells in prostate cancer.
|
| Shiota M, Bishop JL, Nip KM, Zardan A, Takeuchi A, Cordonnier T, Beraldi E, Bazov J, Fazli L, Chi K, Gleave M, Zoubeidi A.
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| Cancer Res 73(10):3109-19. doi: 10.1158/0008-5472.CAN-12-3979. Epub 2013 Mar 14.
2013
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| 17 | HSPB1
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| Promoter hypermethylation of the gene encoding heat shock protein B1 in oral squamous carcinoma cells.
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| Wang HC, Chiang WF, Huang HH, Huang SK, Chiang HC.
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| Oral Surg Oral Med Oral Pathol Oral Radiol 115(3):376-84. doi: 10.1016/j.oooo.2012.12.011.
2013
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| 18 | HSPB1, MAP3K4, SH3KBP1, TNFSF10
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| TRAIL/MEKK4/p38/HSP27/Akt survival network is biphasically modulated by the Src/CIN85/c-Cbl complex.
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| Kim J, Kang D, Sun BK, Kim JH, Song JJ.
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| Cell Signal 25(1):372-9. doi: 10.1016/j.cellsig.2012.10.010. Epub 2012 Oct 23.
2013
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| 19 | HSPB1
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| Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer.
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| Straume O, Shimamura T, Lampa MJ, Carretero J, Øyan AM, Jia D, Borgman CL, Soucheray M, Downing SR, Short SM, Kang SY, Wang S, Chen L, Collett K, Bachmann I, Wong KK, Shapiro GI, Kalland KH, Folkman J, Watnick RS, Akslen LA, Naumov GN.
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| Proc Natl Acad Sci U S A 109(22):8699-704. doi: 10.1073/pnas.1017909109. Epub 2012 May 15.
2012
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| 20 | HSPB1, SMURF2
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| Ubiquitination of heat shock protein 27 is mediated by its interaction with Smad ubiquitination regulatory factor 2 in A549 cells.
|
| Sun Y, Zhou M, Fu D, Xu B, Fang T, Ma Y, Chen J, Zhang J.
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| Exp Lung Res 37(9):568-73. Epub 2011 Oct 3.
2011
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| 21 | CMT2F, HDAC6, HSPB1
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| HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease.
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| d'Ydewalle C, Krishnan J, Chiheb DM, Van Damme P, Irobi J, Kozikowski AP, Vanden Berghe P, Timmerman V, Robberecht W, Van Den Bosch L.
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| Nat Med 17(8):968-74. doi: 10.1038/nm.2396.
2011
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| 22 | CMT2F, HSPB1
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| Small heat-shock protein HSPB1 mutants stabilize microtubules in Charcot-Marie-Tooth neuropathy.
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| Almeida-Souza L, Asselbergh B, d'Ydewalle C, Moonens K, Goethals S, de Winter V, Azmi A, Irobi J, Timmermans JP, Gevaert K, Remaut H, Van Den Bosch L, Timmerman V, Janssens S.
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| J Neurosci 31(43):15320-8. doi: 10.1523/JNEUROSCI.3266-11.2011.
2011
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| 23 | BGLAP, HSPB1
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| Regulation by heat shock protein 27 of osteocalcin synthesis in osteoblasts.
|
| Kato K, Adachi S, Matsushima-Nishiwaki R, Minamitani C, Natsume H, Katagiri Y, Hirose Y, Mizutani J, Tokuda H, Kozawa O, Otsuka T.
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| Endocrinology 152(5):1872-82. doi: 10.1210/en.2010-1062. Epub 2011 Mar 22.
2011
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| 24 | HSPB1, TCHP
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| Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells.
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| Fassan M, D'Arca D, Letko J, Vecchione A, Gardiman MP, McCue P, Wildemore B, Rugge M, Shupp-Byrne D, Gomella LG, Morrione A, Iozzo RV, Baffa R.
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| PLoS One 6(5):e19771. doi: 10.1371/journal.pone.0019771.
2011
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| 25 | HSPB1, HSPB2
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| Heat shock protein 27 is required for sex steroid receptor trafficking to and functioning at the plasma membrane.
|
| Razandi M, Pedram A, Levin ER.
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| Mol Cell Biol 30(13):3249-61. Epub 2010 May 3.PMID: 20439495 2010
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| 26 | HSPB1, MAP3K12
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| The small heat-shock protein Hsp27 undergoes ERK-dependent phosphorylation and redistribution to the cytoskeleton in response to dual leucine zipper-bearing kinase expression.
|
| Robitaille H, Simard-Bisson C, Larouche D, Tanguay RM, Blouin R, Germain L.
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| J Invest Dermatol 130(1):74-85. Epub .
2010
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| 27 | HSPB1
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| Activation of gene transcription by heat shock protein 27 may contribute to its neuronal protection.
|
| Friedman MJ, Li S, Li XJ.
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| J Biol Chem 284(41):27944-51. Epub 2009 Aug 5.PMID: 19656944 2009
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| 28 | HSPB1
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| Hsp-27 expression at diagnosis predicts poor clinical outcome in prostate cancer independent of ETS-gene rearrangement.
|
| Foster CS, Dodson AR, Ambroisine L, Fisher G, Møller H, Clark J, Attard G, De-Bono J, Scardino P, Reuter VE, Cooper CS, Berney DM, Cuzick J.
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| Br J Cancer 101(7):1137-44. Epub 2009 Aug 25.PMID: 19707199 2009
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| 29 | HSPB1
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| Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity.
|
| Brunet Simioni M, De Thonel A, Hammann A, Joly AL, Bossis G, Fourmaux E, Bouchot A, Landry J, Piechaczyk M, Garrido C.
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| Oncogene 28(37):3332-44. Epub 2009 Jul 13.PMID: 19597476 2009
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| 30 | HSPB1
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| The level of Hsp27 in lymphocytes is negatively associated with a higher risk of lung cancer.
|
| Wang F, Feng M, Xu P, Xiao H, Niu P, Yang X, Bai Y, Peng Y, Yao P, Tan H, Tanguay RM, Wu T.
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| Cell Stress Chaperones 14(3):245-51. Epub 2008 Sep 18.PMID: 18800238 2009
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| 31 | HSPB1
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| Serum heat shock protein 27 is increased in chronic pancreatitis and pancreatic carcinoma.
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| Liao WC, Wu MS, Wang HP, Tien YW, Lin JT.
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| Pancreas 38(4):422-6.PMID: 19214136 2009
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| 32 | HSPB1
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| Transduced HSP27 protein protects neuronal cell death by enhancing FALS-associated SOD1 mutant activity.
|
| An JJ, Lee YP, Kim DW, Sohn EJ, Jeong HJ, Kang HW, Shin MJ, Kim MJ, Ahn EH, Jang SH, Kang JH, Kang TC, Won MH, Kwon OS, Cho SW, Lee KS, Park J, Eum WS, Choi SY.
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| BMB Rep 42(3):136-41.PMID: 19335999 2009
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| 33 | HSPB1
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| Elevated HSP27, HSP70 and HSP90 alpha in chronic obstructive pulmonary disease: markers for immune activation and tissue destruction.
|
| Hacker S, Lambers C, Hoetzenecker K, Pollreisz A, Aigner C, Lichtenauer M, Mangold A, Niederpold T, Zimmermann M, Taghavi S, Klepetko W, Ankersmit HJ.
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| Clin Lab 55(1-2):31-40.PMID: 19350847 2009
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| 34 | AR, HSPB1, PRKD1
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| Heat shock protein 27 mediates repression of androgen receptor function by protein kinase D1 in prostate cancer cells.
|
| Hassan S, Biswas MH, Zhang C, Du C, Balaji KC.
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| Oncogene 28(49):4386-96. Epub .PMID: 19767773 2009
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| 35 | HSPB1, MAPKAPK5
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| PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5.
|
| Kostenko S, Johannessen M, Moens U.
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| Cell Signal 21(5):712-8. doi: 10.1016/j.cellsig.2009.01.009. Epub 2009 Jan 8.
2009
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| 36 | CMT2F, HSPB1
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| Mutations in the HSP27 (HSPB1) gene cause dominant, recessive, and sporadic distal HMN/CMT type 2.
|
| Houlden H, Laura M, Wavrant-De Vrièze F, Blake J, Wood N, Reilly MM.
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| Neurology 71(21):1660-8. Epub 2008 Oct 1.PMID: 18832141 2008
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| 37 | HSPB1
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| Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-A.
|
| Rayner K, Chen YX, McNulty M, Simard T, Zhao X, Wells DJ, de Belleroche J, O'Brien ER.
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| Circ Res 103(2):133-41. Epub 2008 Jun 19.PMID: 18566345 2008
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| 38 | HSPB1
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| Heat shock protein 27, a novel regulator of 5-fluorouracil resistance in colon cancer.
|
| Tsuruta M, Nishibori H, Hasegawa H, Ishii Y, Endo T, Kubota T, Kitajima M, Kitagawa Y.
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| Oncol Rep 20(5):1165-72.PMID: 18949417 2008
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| 39 | HSPB1
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| Heat shock protein 27 expression in the human testis showing normal and abnormal spermatogenesis.
|
| Adly MA, Assaf HA, Hussein MR.
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| Cell Biol Int 32(10):1247-55. Epub 2008 Jul 23.PMID: 18692580 2008
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| 40 | CMT2F, HSPB1
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| Asymmetrical late onset motor neuropathy associated with a novel mutation in the small heat shock protein HSPB1 (HSP27).
|
| James PA, Rankin J, Talbot K.
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| J Neurol Neurosurg Psychiatry 79(4):461-3.PMID: 18344398 2008
|
| 41 | HSPB1, CMT2F
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| A mutation in the small heat-shock protein HSPB1 leading to distal hereditary motor neuronopathy disrupts neurofilament assembly and the axonal transport of specific cellular cargoes.
|
| Ackerley S, James PA, Kalli A, French S, Davies KE, Talbot K.
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| Hum Mol Genet 15(2):347-54. Epub 2005 Dec 20. 2006
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| 42 | ALXD1, GFAP, CRYAB, HSPB1
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| The Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of alpha B-crystallin and HSP27.
|
| Der Perng M, Su M, Wen SF, Li R, Gibbon T, Prescott AR, Brenner M, Quinlan RA.
|
| Am J Hum Genet 79(2):197-213. Epub 2006 Jun 12. 2006
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| 43 | HSPB1
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| Expression of heat shock protein 27 in human atherosclerotic plaques and increased plasma level of heat shock protein 27 in patients with acute coronary syndrome.
|
| Park HK, Park EC, Bae SW, Park MY, Kim SW, Yoo HS, Tudev M, Ko YH, Choi YH, Kim S, Kim DI, Kim YW, Lee BB, Yoon JB, Park JE.
|
| Circulation 114(9):886-93. Epub 2006 Aug 21. 2006
|
| 44 | CRYAB, HSPB1, HSPB3, HSPB6, HSPB8
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| Interactions of HSP22 (HSPB8) with HSP20, alphaB-crystallin, and HSPB3.
|
| Fontaine JM, Sun X, Benndorf R, Welsh MJ.
|
| Biochem Biophys Res Commun 337(3):1006-11. Epub 2005 Oct 3. 2005
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| 45 | HSPB1, HSPB2
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| A protective role of 27-kDa heat shock protein in glucocorticoid-evoked apoptotic cell death of hippocampal progenitor cells.
|
| Son GH, Geum D, Chung S, Park E, Lee KH, Choi S, Kim K.
|
| Biochem Biophys Res Commun 338(4):1751-8. Epub 2005 Nov 2. 2005
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| 46 | HSPB1, CMT2F
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| Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
|
| Evgrafov OV, Mersiyanova I, Irobi J, Van Den Bosch L, Dierick I, Leung CL, Schagina O, Verpoorten N, Van Impe K, Fedotov V, Dadali E, Auer-Grumbach M, Windpassinger C, Wagner K, Mitrovic Z, Hilton-Jones D, Talbot K, Martin JJ, Vasserman N, Tverskaya S, Polyakov A, Liem RK, Gettemans J, Robberecht W, De Jonghe P, Timmerman V.
|
| Nat Genet 36(6):602-6. Epub 2004 May 02. 2004
|
| 47 | HSPB8, HSPB1
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| Interaction of human HSP22 (HSPB8) with other small heat shock proteins.
|
| Sun X, Fontaine JM, Rest JS, Shelden EA, Welsh MJ, Benndorf R.
|
| J Biol Chem 279(4):2394-402. Epub 2003 Oct 31. 2004
|
| 48 | HSPB1, LACTB
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| Differential expression of a novel gene in response to hsp27 and cell differentiation in human keratinocytes.
|
| Hell-Pourmojib M, Neuner P, Fischer H, Rezaie S, Kindas-Mugge I, Knobler R, Trautinger F.
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| J Invest Dermatol 119(1):154-9. 2002
|
| 49 | CRYAA,CRYAB,HSPBL1,HSPBL2,HSPBL3,HSPB1,HSPB2,HSPB3,HSPB7
|
| Structure-function studies on small heat shock protein oligomeric assembly and interaction with unfolded polypeptides.
|
| Leroux MR, Melki R, Gordon B, Batelier G, Candido EP.
|
| J Biol Chem 272(39):24646-56 1997
|
| 50 | HSPB1
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| The 29-kDa proteins phosphorylated in thrombin-activated human platelets are forms of the estrogen receptor-related 27-kDa heat shock protein.
|
| Mendelsohn ME, Zhu Y, O'Neill S.
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| Proc Natl Acad Sci U S A 88(24):11212-6 1991
|
| 51 | HSPB1
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| cDNA sequence of a human heat shock protein HSP27.
|
| Carper SW, Rocheleau TA, Storm FK.
|
| Nucleic Acids Res 18(21):6457. No abstract available 1990
|
| 52 | CRYAA,CRYAB,HSPBL1,HSPBL2,HSPBL3,HSPB1,HSPB2,HSPB3,HSPB7
|
| Sequence and organization of genes encoding the human 27 kDa heat shock protein.
|
| Hickey E, Brandon SE, Potter R, Stein G, Stein J, Weber LA.
|
| Nucleic Acids Res 14(10):4127-45 1986
|