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FLASH GENE
Symbol HSD17B2 contributors: npt/ - updated : 14-01-2006
HGNC name hydroxysteroid (17-beta) dehydrogenase 2
HGNC id 5211
Location 16q23.3      Physical location : 82.068.857 - 82.132.138
Synonym name
  • short chain dehydrogenase/reductase family 9C, member 2
  • microsomal 17-beta-hydroxysteroid dehydrogenase
  • testosterone 17-beta-dehydrogenase
  • 20 alpha-hydroxysteroid dehydrogenase
  • Synonym symbol(s) EDH17B2, HSD17, SDR9C2, 20-alpha-HSD, E2DH
    EC.number 1.1.1.62, 1.1.1.63
    DNA
    TYPE functioning gene
    STRUCTURE 63.28 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status provisional
    Map cen - D16S516 - D16S504 - D16S507 - D16S505 - D16S511 - HSD17B2 - D16S422 - D16S520 - qter
    Authors Durocher (95)
    Physical map
    LOC388300 16 LOC388300 DNCL2B 16q23.3 dynein, cytoplasmic, light polypeptide 2B CDYL2 16q23.2 chromodomain protein, Y-like 2 DC13 16q23.2 DC13 protein BM039 16q23.2 uncharacterized bone marrow protein BM039 KIAA0431 16q23.3 uncharacterized bone marrow protein BM039 FLJ32702 16q23.2 hypothetical protein FLJ32702 PKD1L2 16q23.2 polycystic kidney disease 1-like 2 BCDO1 16q21-q23 beta-carotene 15, 15'-dioxygenase GAN 16q24.1 giant axonal neuropathy (gigaxonin) CMIP 16q23 c-Maf-inducing protein FLJ14327 16q23.2 hypothetical protein FLJ14327 LOC388301 16 LOC388301 PLCG2 16q24.1 phospholipase C, gamma 2 (phosphatidylinositol-specific) HSPC105 16q23.2 NAD(P) dependent steroid dehydrogenase-like HSD17B2 16q24.1-q24.2 hydroxysteroid (17-beta) dehydrogenase 2 MPHOSPH6 16q23.1 M-phase phosphoprotein 6 CDH13 16q24.2 cadherin 13, H-cadherin (heart) HSBP1 16q23.3 heat shock factor binding protein 1 MLYCD 16q23-q24 malonyl-CoA decarboxylase OKL38 16q24.1 malonyl-CoA decarboxylase NECAB2 LOC146167 16q24.1 similar to hypothetical protein FLJ10815 MBTPS1 16q24 membrane-bound transcription factor protease, site 1 LOC390743 16 similar to Serine/Threonine protein kinase LOC83693 16q24.1 steroid dehydrogenase-like LOC123872 16q24.1 similar to RIKEN cDNA 4930457P18 TAF1C 16q24 TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1000 - 291 - Labrie (1995)
    unknown function
    5 - 1450 - 387 - Labrie (1995)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Reproductivefemale systemplacenta  highly
     female systemovary  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • short chain alcohol dehydrogenase
  • HOMOLOGY
    Homologene
    FAMILY
  • short-chain dehydrogenases/reductases (sdr) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • 17-beta-hydroxysteroid dehydrogenase, type II, NAD dependent
  • catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone
  • playing an essential role in the formation of active intracellular sex steroids
  • may be involved in the biological inactivation of these sex steroids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS