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FLASH GENE
Symbol HS3ST3A1 contributors: npt/ - updated : 12-02-2008
HGNC name heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HGNC id 5196
Location 17p12      Physical location : 13.399.005 - 13.505.244
Synonym name
  • heparan sulfate 3-O-sulfotransferase 3A1
  • heparin-glucosamine 3-O-sulfotransferase
    • Synonym symbol(s) 3OST3A1, 30ST3A1, 30ST3A1, h3-OST-3A
    EC.number 2.8.2.30
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    text 700kb telomeric to HS3ST3B1 in opposite orientation
    STRUCTURE 106.24 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2546 44.8 406 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   predominantly
    Nervousbrain    
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta (predominantly)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five potential N glycosylation sites
  • four domains
  • a N terminal cytoplasmic tail
  • an hydrophobic transmembrane segment
  • a domain extremely rich in Ser, Pro, Leu, Ala, Gly (SPLAG domain,acting as a flexible stem and a putative C terminal catalytic domain)
    • HOMOLOGY
    interspecies homolog to murine Hs3st3a
    homolog to Drosophila CG7890
    homolog to C.elegans hst-3
    Homologene
    FAMILY
  • sulfotransferase 1 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,Golgi
    text integral membrane protein type II
    basic FUNCTION
  • heparan sulfate D-glucosamine 3-O-sulfotransferase 3A1
  • putative regulator of heparan sulfate proteoglycan properties
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS