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FLASH GENE
Symbol HS3ST3A1 contributors: npt/ - updated : 12-02-2008
HGNC name heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HGNC id 5196
Location 17p12      Physical location : 13.399.005 - 13.505.244
Synonym name
  • heparan sulfate 3-O-sulfotransferase 3A1
  • heparin-glucosamine 3-O-sulfotransferase
  • Synonym symbol(s) 3OST3A1, 30ST3A1, 30ST3A1, h3-OST-3A
    EC.number 2.8.2.30
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    text 700kb telomeric to HS3ST3B1 in opposite orientation
    STRUCTURE 106.24 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC388336 17 similar to hypothetical protein D430041B17 LOC284033 17p13.1 hypothetical protein LOC284033 DNAH9 17p12 dynein, axonemal, heavy polypeptide 9 ZNF18 17p13-p12 zinc finger protein 18 (KOX 11) LOC390763 17 similar to 60S ribosomal protein L21 MAP2K4 17p11.2 mitogen-activated protein kinase kinase 4 FLJ34690 17p12 hypothetical protein FLJ34690 LOC390764 17 similar to hypothetical protein MYCD 17p13.3 similar to hypothetical protein KIAA0672 17p11.2 similar to hypothetical protein ELAC2 17p11.2 elaC homolog 2 (E. coli) HS3ST3A1 17p12-p11.2 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 LOC388337 17 similar to CDRT15 protein COX10 17p12-p11.2 COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) LOC146822 17p12 similar to CDRT15 protein LOC388338 17 LOC388338 HS3ST3B1 17p12-p11.2 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 LOC388339 17 similar to ribosomal protein LOC390765 17 similar to 60S ribosomal protein L23a LOC388340 17 LOC388340 PMP22 17p12-p11.2 peripheral myelin protein 22 TEKT3 17p12 tektin 3 FLJ36674 17p11.2 hypothetical protein FLJ36674 LOC201158 17p11.2 similar to CGI-148 protein C17orf1A 17p11 chromosome 17 open reading frame 1A CDRT1 17p12 CMT1A duplicated region transcript 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2546 44.8 406 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   predominantly
    Nervousbrain    
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta (predominantly)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five potential N glycosylation sites
  • four domains
  • a N terminal cytoplasmic tail
  • an hydrophobic transmembrane segment
  • a domain extremely rich in Ser, Pro, Leu, Ala, Gly (SPLAG domain,acting as a flexible stem and a putative C terminal catalytic domain)
  • HOMOLOGY
    interspecies homolog to murine Hs3st3a
    homolog to Drosophila CG7890
    homolog to C.elegans hst-3
    Homologene
    FAMILY
  • sulfotransferase 1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,Golgi
    text integral membrane protein type II
    basic FUNCTION
  • heparan sulfate D-glucosamine 3-O-sulfotransferase 3A1
  • putative regulator of heparan sulfate proteoglycan properties
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS