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FLASH GENE

Symbol

HS3ST3A1

contributors: npt/ - updated : 12-02-2008

HGNC name	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HGNC id	5196

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	opposite orientation
text	700kb telomeric to HS3ST3B1 in opposite orientation
STRUCTURE	106.24 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed HS3ST3A1 2 - 2546 44.8 406 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       predominantly Nervous brain         Respiratory lung

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta (predominantly)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	five potential N glycosylation sites
	four domains
	a N terminal cytoplasmic tail
	an hydrophobic transmembrane segment
	a domain extremely rich in Ser, Pro, Leu, Ala, Gly (SPLAG domain,acting as a flexible stem and a putative C terminal catalytic domain)

HOMOLOGY

interspecies	homolog to murine Hs3st3a
	homolog to Drosophila CG7890
	homolog to C.elegans hst-3

Homologene

FAMILY

sulfotransferase 1 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,Golgi
text	integral membrane protein type II

basic FUNCTION	heparan sulfate D-glucosamine 3-O-sulfotransferase 3A1
	putative regulator of heparan sulfate proteoglycan properties

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS