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FLASH GENE
Symbol HOXD12 contributors: mct/npt - updated : 18-12-2009
HGNC name homeobox D12
HGNC id 5135
Corresponding disease
PSDY2 polysyndactyly 2
Location 2q31.1      Physical location : 176.964.529 - 176.965.488
Synonym name
  • homeo box D12 (4H)
  • Hox-4.7, mouse, homolog of
  • Synonym symbol(s) HOX4H, HXDC
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, component of a cluster
    STRUCTURE 0.96 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see HOXD@
    Physical map
    KIAA1715 2q31 KIAA1715 LOC344191 2q31.2 similar to Homeobox even-skipped homolog protein 2 (EVX-2) HOXD13 2q31 homeo box D13 HOXD12 2q31 homeo box D12 HOXD11 2q31.1 homeo box D11 HOXD10 2q31 homeo box D10 HOXD9 2q31 homeo box D9 HOXD8 2q31 homeo box D8 HOXD4 2q31 homeo box D4 HOXD3 2q31 homeo box D3 HOXD1 2q31-q37 homeo box D1 LOC150978 2q31.2 similar to 60S acidic ribosomal protein P1 LOC129841 2q31.2 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) MTX2 2q24.3-q31 metaxin 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 813 - 270 - Shen (1997)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • helix-turn-helix, DNA binding domain
  • HOMOLOGY
    interspecies homolog to murine Hox-4.7
    Homologene
    FAMILY
  • ABD-B homeobox family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION unknown
    CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to HOD13 during mouse limb development
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PSDY2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    higher in progesterone receptor-positive cancer tissues than negative cancer tissues (Makiyama 2005)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS